79524-20-2

Basic information

• Product Name: 4-(4-NITROPHENYL)-1-BUTANOL
• Synonyms: 4-(4-NITROPHENYL)-1-BUTANOL;4-(4-nitrophenyl)butan-1-ol;1-(4-Hydroxybutyl)-4-nitrobenzene;4-(4-Nitrophenyl)-1-butanol 95%;4-Nitro-benzenebutanol
• CAS NO: 79524-20-2
• Molecular Formula: C₁₀H₁₃NO₃
• Molecular Weight: 195.22
• EINECS: 279-175-2
• Product Categories: Alcohols;C9 to C30;Oxygen Compounds;Building Blocks;C9 to C10;Chemical Synthesis;Organic Building Blocks;Oxygen Compounds
• Mol File: 79524-20-2.mol
• Article Data: 6

Chemical Properties

• Boiling Point: 356.2 °C at 760 mmHg
• Flash Point: >230 °F
• Appearance: /
• Density: 1.154 g/mL at 25 °C(lit.)
• Vapor Pressure: 1.09E-05mmHg at 25°C
• Refractive Index: n20/D 1.557(lit.)
• CAS DataBase Reference: 4-(4-NITROPHENYL)-1-BUTANOL(CAS DataBase Reference)
• NIST Chemistry Reference: 4-(4-NITROPHENYL)-1-BUTANOL(79524-20-2)
• EPA Substance Registry System: 4-(4-NITROPHENYL)-1-BUTANOL(79524-20-2)

Safety Data

• WGK Germany: 3
• Hazardous Substances Data: 79524-20-2(Hazardous Substances Data)

Usage

Uses

4-(4-Nitrophenyl)-1-butanol was used in chemoenzymatic synthesis of bacterial O-antigen from Salmonella serogroup E1, 3-O-(4-O-β-D-mannopyranosyl-α-L-rhamnopyranosyl)-α-D-galactose.

InChI:InChI=1/C10H13NO3/c12-8-2-1-3-9-4-6-10(7-5-9)11(13)14/h4-7,12H,1-3,8H2

Upstream product

• 5600-62-4 4-(4-nitrophenyl)butanoic acid 

Downstream Products

• 99359-34-9 1-(4-bromobutyl)-4-nitrobenzene 
• 1311295-91-6 4-(4-nitrophenyl)-2-(2,2,6,6-tetramethylpiperidin-1-yloxy)butanal 
• 1052119-86-4 C₅₂H₈₈N₆O₁₃ 
• 1052138-75-6 1-[4-(4-azidobutyl)phenyl]-4-trimethylsilanyl-1H-[1,2,3]triazole 
• 1052138-73-4 4-[4-(4-trimethylsilanyl-[1,2,3]triazol-1-yl)-phenyl]butan-1-ol 
• 864528-97-2 1-[4-(4-azidobutyl)phenyl]-1H-[1,2,3]triazole 
• 1052138-76-7 4-(4-[1,2,3]triazol-1-ylphenyl)butylamine 
• 1052138-70-1 4-(4-azidophenyl)butan-1-ol 
• 1206670-05-4 methyl 2-diazo-2-[4-(4'-nitrophenyl)-butylsulfonyl]acetate 
• 1206670-26-9 methyl 2-[4-(4'-nitrophenyl)-butylsulfonyl]acetate 
• 803730-15-6 4-(4-fluorobutyl)aniline 
• 1448188-55-3 C₁₃H₁₃NO₄ 

Relevant articles and documents

GLYCOSIDE COMPOUND AND PREPARATION METHOD THEREFOR, COMPOSITION, APPLICATION, AND INTERMEDIATE

The present invention discloses a glycoside compound represented by Formula III, and a preparation method, a composition, use and an intermediate thereof. The glycoside compound provided in the present invention has simple preparation method, can significantly increase the expression of VEGF-A mRNA, and is effective in promoting the angiogenesis. This provides a reliable guarantee for the development of drugs with pro-angiogenic activity for treating cerebral infarction cerebral stroke, myocardial infarction, and ischemic microcirculatory disturbance of lower limbs.

Benzoxazolone Carboxamides as Potent Acid Ceramidase Inhibitors: Synthesis and Structure-Activity Relationship (SAR) Studies

Ceramides are lipid-derived intracellular messengers involved in the control of senescence, inflammation, and apoptosis. The cysteine amidase, acid ceramidase (AC), hydrolyzes these substances into sphingosine and fatty acid and, by doing so, regulates their signaling activity. AC inhibitors may be useful in the treatment of pathological conditions, such as cancer, in which ceramide levels are abnormally reduced. Here, we present a systematic SAR investigation of the benzoxazolone carboxamides, a recently described class of AC inhibitors that display high potency and systemic activity in mice. We examined a diverse series of substitutions on both benzoxazolone ring and carboxamide side chain. Several modifications enhanced potency and stability, and one key compound with a balanced activity-stability profile (14) was found to inhibit AC activity in mouse lungs and cerebral cortex after systemic administration. The results expand our arsenal of AC inhibitors, thereby facilitating the use of these compounds as pharmacological tools and their potential development as drug leads.

Topologically Controlled Coulombic Interactions, a New Tool in the Developing of Novel Reactivity. Photochemical and Electrochemical Cleavage of Phenyl Alkyl Ethers

The hypothesis that a specific placement of a positive charge would dramatically alter the behavior of a charged intermediate has been tested.Phenyl ethers substituted by electron-attracting groups do not undergo reductive fragmentation.However, related α-piperidino-ω-(4-substituted-phenoxy)alkanes give alkyl ether photocleavage when the linker between the redox centers is short, or the usual substitution-reduction photochemistry when it is long.Mechanistic experiments suggest that the photofragmentation process operates through space intramolecular electron transfer to the triplet aromatic chromophore and that a coplanar relative orientation of the alkyl ether bond and the phenyl ring is compulsory for the photofragmentation to be observed.Configuration interaction AM1 calculations justify the described facts, indicating that the fragmentation process is only operative when a Coulombic stabilization of a ?* intramolecular electron transfer excited state is produced.Electrochemical studies carried out with the corresponding quaternary salts (intermolecular generation of the phenyl ether radical anion) confirm the conclusions derived from the photochemical experiments.