79642-50-5 Usage
Description
Disuccinimidyl glutarate (DSG) is a homobifunctional crosslinking agent that contains amine-reactive N-hydroxysuccinimide (NHS) ester groups at each end. DSG is membrane-permeable and non-cleavable. DSG can be combined with formaldehyde fixation to improve the detection of specific protein-DNA complexes.
Characteristics
Features of disuccinimidyl glutarate:Reactive groups: NHS ester (both ends)Reactive towards: amino groups (primary amines)Non-cleavableWater-insoluble (dissolve first in DMF or DMSO)Membrane-permeable, allowing for intracellular crosslinkingCan increase crosslinking efficiency compared to DSS in some applications
Uses
Disuccinimidyl glutarate is used as a membrane-soluble, amine-reactive N-hydroxysuccinamide ester-based homobifunctional crosslinking reagent. It is a homobifunctionla cross-linking reagent, for ex. isolation of the insulin receptor.
Check Digit Verification of cas no
The CAS Registry Mumber 79642-50-5 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 7,9,6,4 and 2 respectively; the second part has 2 digits, 5 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 79642-50:
(7*7)+(6*9)+(5*6)+(4*4)+(3*2)+(2*5)+(1*0)=165
165 % 10 = 5
So 79642-50-5 is a valid CAS Registry Number.
79642-50-5Relevant articles and documents
MODIFIED THERAPEUTIC AGENTS AND COMPOSITIONS THEREOF
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Paragraph 0264, (2017/01/02)
Methods and compositions are provided for extending the half-life of a therapeutic agent. A modified therapeutic agent (mTA) comprises a therapeutic agent, a staple, and a half-life extending molecule. The mTAs disclosed herein may be used to treat a disease or a condition in a subject in need thereof.
3D small-molecule microarrays
Marsden, David M.,Nicholson, Rebecca L.,Ladlow, Mark,Spring, David R.
supporting information; experimental part, p. 7107 - 7109 (2010/03/25)
A PEG based 3D hydrogel slide was developed specifically for small-molecule microarraying purposes, which displayed improved loading capacity, signal sensitivity and spot morphology compared with a commercially available slide and comparative 2D slide. The Royal Society of Chemistry 2009.
