79649-68-6

Basic information

• Product Name: Acetamide, N-(1-methyl-1-phenylethyl)-
• CAS NO: 79649-68-6
• Molecular Formula: C11H15NO
• Molecular Weight: 177.246
• Mol File: 79649-68-6.mol
• Article Data: 12

Chemical Properties

• CAS DataBase Reference: Acetamide, N-(1-methyl-1-phenylethyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: Acetamide, N-(1-methyl-1-phenylethyl)-(79649-68-6)
• EPA Substance Registry System: Acetamide, N-(1-methyl-1-phenylethyl)-(79649-68-6)

Safety Data

• Hazardous Substances Data: 79649-68-6(Hazardous Substances Data)

Upstream product

• 108-24-7 acetic anhydride 
• 585-32-0 2-phenyl-2-propylamine 
• 172217-04-8 α,α,α-trifluoro-o-diacetotoluidide 
• 75-36-5 acetyl chloride 
• 4747-74-4 α,α-dimethylbenzyl isocyanate 
• 75-16-1 methylmagnesium bromide 
• 826-55-1 2-methyl-2-phenylpropionic acid 
• 4148-93-0 2-phenyl-2-propyl phenyl sulfide 
• 1309380-98-0 C₁₈H₂₁NO₄S 
• 300561-19-7 N-acetyl-N-(2,3,4,5,6-pentafluorophenyl)methanesulfonamide 
• 60-35-5 acetamide 
• 98-83-9 isopropenylbenzene 
• 98-82-8 Isopropylbenzene 
• 75-05-8 acetonitrile 

Downstream Products

• 857293-82-4 N-(2-(p-nitrophenyl)-2-propyl)acetamide 
• 66896-50-2 dimethylethylbenzylamine 
• 585-32-0 2-phenyl-2-propylamine 
• 917364-23-9 N-{1-methyl-1-[4-(phenylacetyl)phenyl]ethyl}acetamide 
• 60-35-5 acetamide 

Relevant articles and documents

A Copper-Catalyzed Aerobic [1,3]-Nitrogen Shift through Nitrogen-Radical 4-exo-trig Cyclization

A novel radical [1,3]-nitrogen shift catalyzed by copper diacetate under an oxygen atmosphere (1 atm) has been developed for the construction of a diverse range of indole derivatives from α,α-disubstituted benzylamine. In this reaction, oxygen was used as a clean terminal oxidant, and water was produced as the only by-product. Five inert bonds were cleaved, and two C?N bonds and one C?C double bond were constructed in one pot during this transformation. This unique method demonstrated broad application protential for the late-stage modification of biologically active natural products and drugs. Mechanistic investigations indicate that a unique 4-exo-trig cyclization of an aminyl radical onto a phenyl ring is involved in the catalytic cycle.

Dynamic path bifurcation in the Beckmann reaction: Support from kinetic analyses

The reactions of oximes to amides, known as the Beckmann rearrangement, may undergo fragmentation to form carbocations + nitriles when the migrating groups have reasonable stability as cations. The reactions of oxime sulfonates of 1-substituted-phenyl-2-propanone derivatives (7-X) and related substrates (8-X, 9a-X) in aqueous CH3CN gave both rearrangement products (amides) and fragmentation products (alcohols), the ratio of which depends on the system; the reactions of 7-X gave amides predominantly, whereas 9a-X yielded alcohols as the major product. The logk-logk plots between the systems gave excellent linear correlations with slopes of near unity. The results support the occurrence of path bifurcation after the rate-determining TS of the Beckmann rearrangement/fragmentation reaction, which has previously been proposed on the basis of molecular dynamics simulations. It was concluded that path-bifurcation phenomenon could be more common than thought and that a reactivity-selectivity argument based on the traditional TS theory may not always be applicable even to a well-known textbook organic reaction.

Catalytic oxidation of C-H bonds

The invention provides a catalytic, chemospecific and stereospecific method of oxidizing a wide variety of substrates without unwanted side reactions. Essentially, the method of the instant invention, under relatively mild reaction conditions, catalytically, stereospecifically and chemospecifically inserts oxygen into a hydrocarbon C—H bond. Oxidation (oxygen insertion) at a tertiary C—H bond to form an alcohol (and in some cases a hemiacetal) at the tertiary carbon is favored. The stereochemistry of an oxidized tertiary carbon is preserved. Ketones are formed by oxidizing a secondary C—H bond and ring-cleaved diones are formed by oxidizing cis tertiary CH bonds.