796845-51-7Relevant articles and documents
Structural requirements for the stability of novel cephalosporins to AmpC β-lactamase based on 3D-structure
Murano, Kenji,Yamanaka, Toshio,Toda, Ayako,Ohki, Hidenori,Okuda, Shinya,Kawabata, Kohji,Hatano, Kazuo,Takeda, Shinobu,Akamatsu, Hisashi,Itoh, Kenji,Misumi, Keiji,Inoue, Satoshi,Takagi, Tatsuya
, p. 2261 - 2275 (2008/12/20)
AmpC β-lactamase is one of the leading causes of Pseudomonas aeruginosa (P. aeruginosa) resistance to cephalosporins. FR259647 is a cephalosporin having a novel pyrazolium substituent at the 3-position and exhibits excellent activity (MIC = 1 μg/mL) again