796870-93-4

Basic information

• Product Name: 1H-Indole-2-carboxylicacid,5-ethyl-,methylester(9CI)
• Synonyms: 1H-Indole-2-carboxylicacid,5-ethyl-,methylester(9CI)
• CAS NO: 796870-93-4
• Molecular Formula: C12H13NO2
• Molecular Weight: 0
• Product Categories: ETHYL
• Mol File: 796870-93-4.mol
• Article Data: 1

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 1H-Indole-2-carboxylicacid,5-ethyl-,methylester(9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: 1H-Indole-2-carboxylicacid,5-ethyl-,methylester(9CI)(796870-93-4)
• EPA Substance Registry System: 1H-Indole-2-carboxylicacid,5-ethyl-,methylester(9CI)(796870-93-4)

Safety Data

• Hazardous Substances Data: 796870-93-4(Hazardous Substances Data)

Upstream product

• 796870-37-6 C₁₂H₁₁NO₂ 

Downstream Products

• 37033-93-5 5-ethyl-1H-indole-2-carboxylic acid 

Relevant articles and documents

CBI analogues of the duocarmycins and CC-1065

An extensive series of CBI analogues of the duocarmycins and CC-1065 exploring substituent effects within the first indole DNA binding subunit is detailed. In general, substitution at the indole C5 position led to cytotoxic potency enhancements that can be ≧1000-fold providing simplified analogues containing a single DNA binding subunit that are more potent (IC50=2-3 pM) than CBI-TMI, duocarmycin SA, or CC-1065. The increases in cytotoxicity correlate well with accompanying increases in the rate and efficiency of DNA alkylation. This effect is more pronounced with the CBI versus DSA or CPI based analogues. Moreover, this effect is largely insensitive to the electronic character of the C5 substituent but is sensitive to the size, rigid length, and shape (sp, sp2, sp3 hybridization) of this substituent consistent with expectation that the impact is due simply to its presence.