79719-29-2Relevant articles and documents
The Design and Synthesis of ALS Inhibitors from Pharmacophore Models
Liu, Jie,Li, Zhengming,Yan, Han,Wang, Lingxiu,Chen, Junpeng
, p. 1927 - 1932 (1999)
In search of new ALS inhibitors without the previous knowledge of receptor crystal structure, DISCO module was applied to produce 3D-pharmacophore models, which provided information to design novel molecules by 3D-database searching. Then a number of molecules were synthesized. Several of them have some ALS inhibitory activities.