79750-90-6

Basic information

• Product Name: ethyl 2-[(4-methoxybenzoyl)amino]-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxylate
• Synonyms: ethyl 2-[(4-methoxybenzoyl)amino]-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxylate
• CAS NO: 79750-90-6
• Molecular Formula: C₁₉H₂₁NO₄S
• Molecular Weight: 359.43934
• Mol File: 79750-90-6.mol
• Article Data: 3

Chemical Properties

• Melting Point: 158-160 °C(Solv: ethanol (64-17-5))
• Boiling Point: 479.0±45.0 °C(Predicted)
• Appearance: /
• Density: 1.270±0.06 g/cm3(Predicted)
• PKA: 12.84±0.20(Predicted)
• CAS DataBase Reference: ethyl 2-[(4-methoxybenzoyl)amino]-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: ethyl 2-[(4-methoxybenzoyl)amino]-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxylate(79750-90-6)
• EPA Substance Registry System: ethyl 2-[(4-methoxybenzoyl)amino]-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxylate(79750-90-6)

Safety Data

• Hazardous Substances Data: 79750-90-6(Hazardous Substances Data)

Upstream product

• 100-09-4 4-methoxybenzoic acid 
• 141-97-9 ethyl acetoacetate 
• 108-94-1 cyclohexanone 
• 105-56-6 ethyl 2-cyanoacetate 
• 4506-71-2 ethyl 2-amino-4,5,6,7-tetrahydrobenzo[b]thiophene-3-carboxylate 
• 100-07-2 4-methoxy-benzoyl chloride 

Downstream Products

• 749219-12-3 TLSC₇₀₃ 
• 79750-93-9 2-(4-Methoxyphenyl)-5,6,7,8-tetrahydro-4H-<1>benzothieno<2,3-d><1,3>oxazin-4-on 

Relevant articles and documents

Preparation method and application of tetrahydrobenzothiophene compound and pharmaceutical composition

The invention belongs to the field of medicines, and particularly relates to a tetrahydrobenzothiophene compound as well as a pharmaceutical composition and a preparation method and application thereof. The tetrahydrobenzothiophene compound is a compound I as shown I. In-flight R1 And R2 The C1 -4 is a saturated/unsaturated hydrocarbon group. - OCH3 , OCH2 CH3 Phenyl, substituted phenyl, NO2 One - COR of - OH - F, Cl - Br. I - H R1 AND R2 Or different. R3 It is-F. - Cl, Br, I, OH, Amino, C1 -4 saturated/unsaturated hydrocarbon group, OCH3 , OCH2 CH3 , H, Wherein one of them is, n ≥ 5, n Being an integer. The compound effectively inhibits salmonella by inhibiting the synthesis of ATP-dependent transporter in the lipopolysaccharide synthesis pathway. Aeruginosa, escherichia coli and staphylococcus aureus.

Heterocyclic β-Enamino Esters, 27. Synthesis of Heterocondensed 6H-1,3-Oxazin-6-ones from N-Acylenamino Esters in the System Triphenylphosphane/Hexachloroethane/Triethylamine

A simple ring closure reaction of N-acylenamino esters (1b, e, 2, 3a - f, 7) in the system triphenylphosphane/hexachloroethane/triethylamine is described proceeding with high yields.Under chlorinating 3-ester cleavage heterocondensed 6H-1,3-oxazin-6-ones