79756-87-9

Basic information

• Product Name: Benzene, 1-(1-propynyl)-4-(trifluoromethyl)-
• CAS NO: 79756-87-9
• Molecular Formula: C10H7F3
• Molecular Weight: 184.161
• Mol File: 79756-87-9.mol
• Article Data: 20

Chemical Properties

• CAS DataBase Reference: Benzene, 1-(1-propynyl)-4-(trifluoromethyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: Benzene, 1-(1-propynyl)-4-(trifluoromethyl)-(79756-87-9)
• EPA Substance Registry System: Benzene, 1-(1-propynyl)-4-(trifluoromethyl)-(79756-87-9)

Safety Data

• Hazardous Substances Data: 79756-87-9(Hazardous Substances Data)

Upstream product

• 402-43-7 p-trifluoromethylphenyl bromide 
• 74-99-7 prop-1-yne 
• 75-20-7 calcium carbide 
• 198012-02-1 4-methyl-N-(4-trifluoromethylbenzylidene)-benzenesulfonamide 
• 503-17-3 dimethylacetylene 
• 119757-51-6 1,2-bis(4-(trifluoromethyl)phenyl)ethyne 
• 455-13-0 4-Iodobenzotrifluoride 
• 590-93-2 2-Butynoic acid 
• 126065-77-8 1-(1,1,2-Trichloro-propyl)-4-trifluoromethyl-benzene 
• 705-31-7 4-trifluoromethylphenylacetylene 
• 74-88-4 methyl iodide 
• 1469462-84-7 1-cyano-1-(4-(trifluoromethyl)phenyl)ethyl diethyl phosphate 
• 1737-26-4 1-(4-trifluorophenyl)ethanol 
• 126065-85-8 1,2-dichloro-1-(4-trifluoromethylphenyl)propene 

Downstream Products

• 1104636-13-6 1-(ferroceneylethynyl)-4-(trifluoromethyl)benzene 
• 1239367-85-1 Ti((2-NC₅H₄)CMe(CH₂NSiMe₃)2)[N(NPh₂)C(Me)C(4-C₆H₄CF₃)] 
• 1350770-14-7 3,6-dimethyl-4-phenyl-2-(4-(trifluoromethyl)phenyl)pyridine 
• 1350770-22-7 C₂₀H₁₆F₃N 
• 1217436-12-8 (Z)-4,4,5,5-tetramethyl-2-(1-(4-(trifluoromethyl)phenyl)prop-1-en-2-yl)-1,3,2-dioxaborolane 
• 138971-33-2 1-((Z)-Hexa-1,5-dienyl)-4-trifluoromethyl-benzene 

Relevant articles and documents

Enantioselective Addition of α-Nitroesters to Alkynes

By using Rh–H catalysis, we couple α-nitroesters and alkynes to prepare α-amino-acid precursors. This atom-economical strategy generates two contiguous stereocenters, with high enantio- and diastereocontrol. In this transformation, the alkyne undergoes isomerization to generate a RhIII–π-allyl electrophile, which is trapped by an α-nitroester nucleophile. A subsequent reduction with In powder transforms the allylic α-nitroesters to the corresponding α,α-disubstituted α-amino esters.

Palladium-catalyzed methylation of terminal alkynes

In this communication, a palladium-catalyzed procedure for the methylation of terminal alkynes has been developed. With N,N,N-trimethylbenzenaminium trifluoromethanesulfonate as the methyl source, various desired products were obtained in moderate to good yields. Both aromatic and aliphatic alkynes are applicable.

A Pd-catalyzed domino Larock annulation/dearomative Heck reaction

A palladium-catalyzed domino Larock annulation/dearomative Heck reaction is developed, which delivers a range of tetracyclic indoline derivatives in moderate to excellent yields through a Larock annulation of N-bromobenzoyl o-iodoanilines with alkynes and a subsequent intramolecular dearomative Heck reaction. This protocol provides a straightforward route to structurally diverse indolines from readily available starting materials by forming two new rings and three chemical bonds in a single step.