797799-58-7

Basic information

• Product Name: 2-methyl-2-phenyl-1,3-oxathiolan-5-one
• Synonyms: 2-methyl-2-phenyl-1,3-oxathiolan-5-one
• CAS NO: 797799-58-7
• Molecular Weight: 194.254
• Mol File: 797799-58-7.mol
• Article Data: 7

Chemical Properties

• CAS DataBase Reference: 2-methyl-2-phenyl-1,3-oxathiolan-5-one(CAS DataBase Reference)
• NIST Chemistry Reference: 2-methyl-2-phenyl-1,3-oxathiolan-5-one(797799-58-7)
• EPA Substance Registry System: 2-methyl-2-phenyl-1,3-oxathiolan-5-one(797799-58-7)

Safety Data

• Hazardous Substances Data: 797799-58-7(Hazardous Substances Data)

Upstream product

• 68-11-1 mercaptoacetic acid 
• 98-86-2 acetophenone 
• 15810-20-5 2,2’-((1-phenylethane-1,1-diyl)bis(sulfanediyl))diacetic acid 

Relevant articles and documents

Masked mercapto acid-driven MCR in task-specific ionic liquid: A new sterocontrolled entry into bicyclic 1,3-thiazines

An unprecedented multi-component reaction for the synthesis of thiosugar-annulated 1,3-thiazines is reported. The envisaged synthetic strategy involves the reaction of d-glucose/d-xylose and 2-methyl-2-phenyl-1,3- oxathiolan-5-one with AcONH4/RNH2 in task specific ionic liquid (TSIL), [bmim]SCN which afforded thiosugar annulated 1,3-thiazines in excellent yields (83-93%). The reaction is effected via ionic liquid promoted Michael addition followed by mercaptoacetylative ring transformation in a one-pot procedure and the ionic liquid, [bmim]OH could be easily recycled for further use without any loss of efficiency and be used for the synthesis of [bmim]SCN, thus allowing recycling of the TSIL for further use.

Catalyst-free, step and pot economic, efficient mercaptoacetylative cyclisation in H2O: Synthesis of 3-mercaptocoumarins

A novel, environmentally friendly, tandem Knoevenagel condensation and mercaptoacetylative cyclisation procedure is reported. The reaction between 2-methyl-2-phenyl-1,3-oxathiolan-5-one and a variety of salicylaldehydes was carried out in water to afford

Mercaptoacetic acid based expeditious synthesis of polyfunctionalised 1,3-thiazines

A novel three-component expeditious synthesis of 3,6-diaryl-5- mercaptoperhydro-2-thioxo-1,3-thiazin-5-ones from 2-methyl-2-phenyl-1,3- oxathiolan-5-one, an aromatic aldehyde and an N-aryldithiocarbamic acid is reported. The synthesis is diastereoselective and involves tandem Knoevenagel, Michael and ring transformation reactions under solvent-free microwave irradiation in a one-pot procedure.

An unprecedented synthesis of γ-lactams via mercaptoacetylation of aziridines in water

A highly green and expeditious route to α-mercapto-γ-lactams from masked mercapto acids viz. 2-phenyl-2-methyl-1,3-oxathiolan-5-ones, and tosyl aziridines in an excellent yield (82-93%) is reported. The synthetic protocol involves regioselective opening of the terminal aziridine ring and mercaptoacetylative cyclisation cascades in a one-pot procedure wherein water acts as both a catalyst as well as a solvent. These reactions were carried out in aqueous media as well as under solvent-free conditions, however, under solvent-free conditions, lower yields are obtained.