79814-60-1Relevant articles and documents
Total synthesis of (+)-compactin by a double Michael protocol
Hagiwara, Hisahiro,Nakano, Takashi,Kon-no, Masakazu,Uda, Hisashi
, p. 777 - 784 (2007/10/02)
The total synthesis of (+)-compactin 1 has been achieved by employing a double Michael reaction of (R)-1-acetyl-3-(tert-butyldimethylsiloxy)cyclohexene 16 with methyl crotonate as the key reaction.
Total synthesis of the hypocholesterolemic agent compactin
Hsu,Wang,Latimer,Sih
, p. 593 - 601 (2007/10/02)
A total synthesis of ( plus )-compactin (ML-236B), a potent inhibitor of 3-hydroxy-3-methylglutaryl coenzyme A reductase, is presented. The key chiral hexahydronaphthalene intermediate was efficiently synthesized in 70% overall yield from the optically active diol. In turn, the diol was obtained via microbiological reduction of the racemic dione. ( plus )-Compactin was prepared in 14 steps from the chiral hexahydronaphthalene intermediate in 0. 8% yield. Refs.
The total synthesis of (±) compactin and its natural (+) enantiomer
Girotra,Wendler
, p. 5501 - 5504 (2007/10/02)
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