79822-58-5Relevant articles and documents
Palladium-catalyzed novel arylations of cyclic β-bromo α,β-unsaturated aldehydes with triarylbismuths as multicoupling organometallic nucleo-philes
Rao, Maddali L. N.,Banerjee, Debasis,Dhanorkar, Ritesh J.
supporting information; experimental part, p. 273 - 279 (2011/04/16)
Cross-coupling arylations of cyclic β-bromo α,β -unsaturated aldehydes were carried out with triarylbismuths as atom-efficient multicoupling organometallic reagents under palladium-catalyzed conditions. These reactions afforded the corresponding arylated alkenes in an efficient manner with good to high yields. Georg Thieme Verlag Stuttgart.
Propenyl Carboxamide Derivatives as Antagonists of Platelet Activating Factor
Guthrie, Robert W.,Kaplan, Gerald L.,Mennona, Francis A.,Tilley, Jefferson W.,Kierstead, Richard W.,et al.
, p. 2856 - 2864 (2007/10/02)
A series of N- 3-substituted propenyl carboxamide derivatives bearing an unsaturated bicyclic moiety in the 3-position was prepared and evaluated for PAF (platelet activating factor) antagonist activity.These compounds represent conformationally constrained direct analogues of the corresponding potent 5-arylpentadienecarboxamides (5).Most of the new compounds were active in a PAF-binding assay employing whole, washed dog platelets as the receptor source and inhibited PAF-induced bronchoconstriction in guinea pigs after intravenous administration.However, oral activity in the PAF-induced bronchoconstriction model was highly sensitive to the nature and substitution of the bicyclic ring system.The most interesting compounds included -(1-butyl-6-methoxy-2-naphthyl)-N--2-propenamide (4b), -(3-butyl-6-methoxy-2-benzothiophene-yl)-N--2-propenamide (4k), and -(3-butyl-6-methoxy-1-methyl-2-indolyl)-N--2-propenamide (4l) which inhibited PAF-induced bronchoconstriction in guinea pigs with IC50s of 3.0-5.4 mg/kg, when the animals were challenged 2 h after drug treatment.They were also highly effective 6 h after a 50 mg/kg oral dose.This study supports the notion that the key remote aromatic ring present in the 5-arylpentadienecarboxamides (5) is preferentially coplanar with the diene system for good PAF antagonist activity.
Applications of the Vilsmeier Reaction. 13. Vilsmeier Approach to Polycyclic Aromatic Hydrocarbons
Reddy, M. Parameswara,Rao, G. S. Krishna
, p. 5371 - 5373 (2007/10/02)
The synthesis of three typical polycyclic hydrocarbons (PAH) has been described, wherein the Vilsmeier reaction plays a major role.Vilsmeier reaction of the tetralol 1 gives the dihydronaphthaldehyde 2 which on cyclodehydration gives the dihydroarene 3.It
