79877-53-5Relevant articles and documents
Preparation method of 2-substituted benzimidazole compound
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Paragraph 0079-0083, (2021/02/20)
The invention discloses a preparation method of a 2-substituted benzimidazole compound, and belongs to the field of synthesis of benzimidazole compounds. The 2-substituted benzimidazole compound is synthesized in an organic solvent by taking an o-nitroaniline compound, aromatic aldehyde, o-dinitrobenzene and aromatic aldehyde as raw materials and taking Co particles wrapped by a nitrogen-doped carbon material as a catalyst. According to the method, the 2-substituted benzimidazole compound can be prepared at room temperature, the reaction conditions are mild, the yield is as high as 95%, the selectivity is as high as 99%, and the method is economical, environmentally friendly and wide in substrate applicability. The used catalyst is easy to prepare, low in cost and good in reusability, canbe separated by utilizing magnetism, and is convenient to recover, so that the method has a relatively strong industrial application prospect.
H2 Activation with Co Nanoparticles Encapsulated in N-Doped Carbon Nanotubes for Green Synthesis of Benzimidazoles
Lin, Chuncheng,Wan, Weihao,Wei, Xueting,Chen, Jinzhu
, p. 709 - 720 (2020/11/30)
Co nanoparticles (NPs) encapsulated in N-doped carbon nanotubes (Co@NC900) are systematically investigated as a potential alternative to precious Pt-group catalysts for hydrogenative heterocyclization reactions. Co@NC900 can efficiently catalyze hydrogenative coupling of 2-nitroaniline to benzaldehyde for synthesis of 2-phenyl-1H-benzo[d]imidazole with >99 % yield at ambient temperature in one step. The robust Co@NC900 catalyst can be easily recovered by an external magnetic field after the reaction and readily recycled for at least six times without any evident decrease in activity. Kinetic experiments indicate that Co@NC900-promoted hydrogenation is the rate-determining step with a total apparent activation energy of 41±1 kJ mol?1. Theoretical investigations further reveal that Co@NC900 can activate both H2 and the nitro group of 2-nitroaniline. The observed energy barrier for H2 dissociation is only 2.70 eV in the rate-determining step, owing to the presence of confined Co NPs in Co@NC900. Potential industrial application of the earth-abundant and non-noble transition metal catalysts is also explored for green and efficient synthesis of heterocyclic compounds.
Preparation method of 2-aryl benzimidazole compound
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Paragraph 0045-0049, (2020/07/15)
The invention discloses a preparation method of a 2-aryl benzimidazole compound. The preparation method comprises the following steps: (1) adding a cyanobenzene compound, an o-phenylenediamine compound, an alkali, a catalyst and an organic solvent into a reactor for reaction; and (2) after the reaction is finished, cooling, removing the solvent, extracting, washing, drying, filtering, and removingthe solvent to obtain a target product; and (3) purifying the target product by column chromatography to obtain the 2-aryl benzimidazole compound. According to the method, the defect that a large amount of acid and a complex metal catalyst system need to be used in a traditional method is overcome, the reaction condition is mild, the severe condition that high temperature is needed in the reaction is avoided, the catalyst is cheap and easy to obtain, the preparation cost is greatly reduced, energy consumption is reduced, the method is simple, and the product yield is high.
