79971-08-7 Usage
Description
2'-Deoxyguanosine 3',5'-Dibutanoate, also known as dG(Bu)2, is a synthetic nucleoside analog that plays a crucial role in the study of DNA adducts. It is derived from the natural nucleoside 2'-deoxyguanosine by the addition of two butanoate groups at the 3' and 5' positions. This modification allows for the investigation of the effects of bulky adducts on DNA structure and function, as well as their implications in mutagenesis and carcinogenesis.
Used in Chemical Synthesis:
2'-Deoxyguanosine 3',5'-Dibutanoate is used as an intermediate in the synthesis of DNA adducts of Aflatoxin B1 (A357460). Aflatoxin B1 is a potent carcinogen produced by Aspergillus species, and its interaction with DNA can lead to the formation of adducts that may cause mutations and contribute to the development of cancer. The use of dG(Bu)2 in the synthesis of these adducts enables researchers to study the mechanisms of DNA damage, repair, and the potential for carcinogenesis.
Used in Research and Development:
In the field of molecular biology and cancer research, 2'-Deoxyguanosine 3',5'-Dibutanoate is used as a tool to investigate the effects of bulky adducts on DNA structure, stability, and replication. By incorporating dG(Bu)2 into DNA molecules, researchers can examine the impact of these modifications on the DNA helix, as well as the ability of DNA polymerases and other enzymes to recognize and process the adducts. This information is crucial for understanding the molecular basis of mutagenesis and the development of strategies to prevent or repair DNA damage caused by environmental carcinogens.
Used in Drug Development:
2'-Deoxyguanosine 3',5'-Dibutanoate may also have potential applications in the development of new drugs and therapies targeting DNA repair mechanisms or the inhibition of carcinogen-DNA interactions. By studying the properties and effects of dG(Bu)2 and its analogs, researchers can identify potential lead compounds or design novel molecules with improved efficacy and selectivity in modulating DNA repair pathways or preventing the formation of harmful DNA adducts.
Check Digit Verification of cas no
The CAS Registry Mumber 79971-08-7 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 7,9,9,7 and 1 respectively; the second part has 2 digits, 0 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 79971-08:
(7*7)+(6*9)+(5*9)+(4*7)+(3*1)+(2*0)+(1*8)=187
187 % 10 = 7
So 79971-08-7 is a valid CAS Registry Number.
