799814-30-5

Basic information

• Product Name: 2-difluoromethylbenzonitrile
• Synonyms: 2-difluoromethylbenzonitrile;2-Cyanobenzal fluoride, alpha,alpha-Difluoro-o-tolunitrile
• CAS NO: 799814-30-5
• Molecular Formula: C₈H₅F₂N
• Molecular Weight: 153.1288064
• Mol File: 799814-30-5.mol
• Article Data: 8

Chemical Properties

• Boiling Point: 233.7±35.0 °C(Predicted)
• Appearance: /
• Density: 1.20±0.1 g/cm3(Predicted)
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 2-difluoromethylbenzonitrile(CAS DataBase Reference)
• NIST Chemistry Reference: 2-difluoromethylbenzonitrile(799814-30-5)
• EPA Substance Registry System: 2-difluoromethylbenzonitrile(799814-30-5)

Safety Data

• Hazardous Substances Data: 799814-30-5(Hazardous Substances Data)

Usage

General Description

2-difluoromethylbenzonitrile is a chemical compound with the molecular formula C8H5F2N. It is a colorless liquid with a faint sweet and floral odor. 2-difluoromethylbenzonitrile is commonly used in the pharmaceutical and agrochemical industries as a building block for the synthesis of various compounds. It is also utilized in the production of dyes and pigments. This chemical is flammable and should be handled with caution, as it can cause irritation to the skin, eyes, and respiratory system. 2-difluoromethylbenzonitrile may also have harmful effects on aquatic organisms and the environment, and proper safety measures should be followed when working with this compound.

Upstream product

• 1511-62-2 bromodifluoromethane 
• 2042-37-7 o-cyanobromobenzene 
• 4387-36-4 2-iodobenzonitrile 
• 1438388-96-5 tributyl(difluoromethyl)stannane 
• 1335290-31-7 ethyl 2-(2-cyanophenyl)-2,2-difluoroacetate 
• 1824201-60-6 2-cyanobenzenedifluoroacetic acid 
• 7468-67-9 o-formylbenzonitrile 

Downstream Products

• 799814-32-7 2-(difluoromethyl)benzoic acid 

Relevant articles and documents

Difluoromethyl-substituted compound (by machine translation)

[Problem] to provide a, simple and inexpensive manufacturing method is difluoromethyl substituted compounds using a reagent. [Solution] a method for producing a compound using a catalyst [...] difluoromethyl-substituted,(I) the catalyst, a nickel compound and nitrogen in the bidentate ligand, raw Ar a-Z " in the formula, the Ar, substituted or unsubstituted aryl group or a substituted or unsubstituted 5 - 10 membered heteroaryl group C6 a-14, Z is, (OR) B2 Or a group represented by a is represented MgX. " Compound represented, difluoromethyl-substituted compounds, Ar e CF2 A method for producing a compound represented by H, or(II) catalyst, a palladium compound and a diphosphine ligand, raw material is Q-a B (OR1 )2 " In the formula, Q is, substituted or unsubstituted aryl C6 a-10, 5 - 10 membered heteroaryl or substituted or unsubstituted, or Ar1 A group represented by - CH=CH - shown. R1 Is, a hydrogen atom or an alkyl group C1 a-6. " Compounds, a compound represented by Q-a Zn-to-Q or, difluoromethyl-substituted compounds, Q-to-CF2 A method for producing a compound represented by H. [Drawing] no (by machine translation)

Metallaphotoredox Difluoromethylation of Aryl Bromides

Herein, we report a convenient and broadly applicable strategy for the difluoromethylation of aryl bromides by metallaphotoredox catalysis. Bromodifluoromethane, a simple and commercially available alkyl halide, is harnessed as an effective source of difluoromethyl radical by silyl-radical-mediated halogen abstraction. The merger of this fluoroalkyl electrophile activation pathway with a dual nickel/photoredox catalytic platform enables the difluoromethylation of a diverse array of aryl and heteroaryl bromides under mild conditions. The utility of this procedure is showcased in the late-stage functionalization of several drug analogues.

Copper-Catalyzed Difluoromethylation of Aryl Iodides with (Difluoromethyl)zinc Reagent

The combination of difluoroiodomethane and zinc dust or diethylzinc can readily lead to (difluoromethyl)zinc reagents. Therefore, the first copper-catalyzed difluoromethylation of aryl iodides with the zinc reagents is accomplished to afford the difluorom