80016-36-0

Basic information

• Product Name: 4-bromo-5,6-dihydrocyclopenta[c]pyrrole-1,3(2H,4H)-dione
• CAS NO: 80016-36-0
• Molecular Formula: C₇H₆BrNO₂
• Molecular Weight: 216.032
• Mol File: 80016-36-0.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 362.6°C at 760 mmHg
• Flash Point: 173.1°C
• Density: 1.85g/cm³
• Vapor Pressure: 1.91E-05mmHg at 25°C
• Refractive Index: 1.631
• CAS DataBase Reference: 4-bromo-5,6-dihydrocyclopenta[c]pyrrole-1,3(2H,4H)-dione(CAS DataBase Reference)
• NIST Chemistry Reference: 4-bromo-5,6-dihydrocyclopenta[c]pyrrole-1,3(2H,4H)-dione(80016-36-0)
• EPA Substance Registry System: 4-bromo-5,6-dihydrocyclopenta[c]pyrrole-1,3(2H,4H)-dione(80016-36-0)

Safety Data

• Hazardous Substances Data: 80016-36-0(Hazardous Substances Data)

Upstream product

• 62291-38-7 2,4-dioxo-3-azabicyclo<3.3.0>oct-Δ^1,5-ene 
• 3128-15-2 cyclopent-1-ene-1,2-dicarboxylic acid 
• 122539-74-6 2-trifluoromethanesulfonyloxy-cyclopent-1-enecarboxylic acid ethyl ester 
• 611-10-9 2-ethoxycarbonyl-1-cyclopentanone 

Downstream Products

• 50988-16-4 (R/S)-4-hydroxy-5,6-dihydrocyclopenta[c]pyrrole-1,3(2H,4H)-dione 
• 50988-16-4 (S)-4-hydroxy-5,6-dihydrocyclopenta[c]pyrrole-1,3(2H,4H)-dione 

Relevant articles and documents

Iso-maleimycin, a Constitutional Isomer of Maleimycin, from Streptomyces sp. QL37

Iso-maleimycin, a previously unknown constitutional isomer of the antibiotic maleimycin, has been detected in an extract of Streptomyces sp. QL37. Chemical synthesis of both maleimycin (20 % yield over seven steps) and iso-maleimycin, (15 % yield over six steps) allowed access to reference materials for identification. Gas Chromatography coupled Mass Spectrometry (GC-MS) analysis demonstrated that of the two isomers, only iso-maleimycin was present in the extract. This finding supports our hypothesis that iso-maleimycin is a biosynthetic intermediate of lugdunomycin. Iso-maleimycin displays low antibiotic activity, with a Minimum Inhibitory Concentration (MIC) value on both E. coli and B. subtilis of 250 μg/mL.

First synthesis of nitrosporeusines, alkaloids with multiple biological activities

Synthesis of nitrosporeusines A and B, thioester-bearing alkaloids from the Arctic Streptomyces nitrosporeus with exceptional biological activity is disclosed for the first time. In addition, we have prepared another biologically important natural product