800401-68-7 Usage
Description
5-Chloro-1H-pyrrolo[2,3-c]pyridine-2-carboxylic acid is a chemical compound characterized by its unique structure, which consists of a pyrrolo[2,3-c]pyridine core with a carboxylic acid group at the 2-position and a chlorine atom at the 5-position. 5-chloro-1H-pyrrolo[2,3-c]pyridine-2-carboxylic acid serves as an important building block in the synthesis of various pharmaceuticals and bioactive molecules.
Uses
Used in Pharmaceutical Industry:
5-Chloro-1H-pyrrolo[2,3-c]pyridine-2-carboxylic acid is used as a key reactant for the preparation of pyrrolopyridinecarboxylic acid amides. These amides are known to be potent inhibitors of glycogen phosphorylase, an enzyme that plays a crucial role in the regulation of glycogen metabolism. By inhibiting this enzyme, these compounds can potentially be used in the development of treatments for various metabolic disorders, such as type 2 diabetes and obesity.
Additionally, the unique structure of 5-chloro-1H-pyrrolo[2,3-c]pyridine-2-carboxylic acid allows for further chemical modifications and functionalization, enabling the synthesis of a wide range of bioactive molecules with diverse therapeutic applications. This makes it a valuable intermediate in the field of medicinal chemistry and drug discovery.
Check Digit Verification of cas no
The CAS Registry Mumber 800401-68-7 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 8,0,0,4,0 and 1 respectively; the second part has 2 digits, 6 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 800401-68:
(8*8)+(7*0)+(6*0)+(5*4)+(4*0)+(3*1)+(2*6)+(1*8)=107
107 % 10 = 7
So 800401-68-7 is a valid CAS Registry Number.
InChI:InChI=1/C8H5ClN2O2/c9-7-2-4-1-5(8(12)13)11-6(4)3-10-7/h1-3,11H,(H,12,13)
800401-68-7Relevant articles and documents
Synthesis of the new ring system bispyrido[4',3':4,5]pyrrolo [1,2-a:1',2'-d]pyrazine and its deaza analogue
Parrino, Barbara,Span, Virginia,Carbone, Anna,Barraja, Paola,Diana, Patrizia,Cirrincione, Girolamo,Montalbano, Alessandra
, p. 13342 - 13357 (2015/02/19)
Derivatives of the new ring systems bispyrido[4',3':4,5]pyrrolo[1,2-a:1',2'-d] pyrazine-6,13-dione and its deaza analogue pyrido[4",3":4',5']pyrrolo-[1',2':4,5]pyrazino [1,2-a]indole-6,13-dione were conveniently synthesized through a four-step sequence. Symmetrical derivatives of the former ring system were obtained through self condensation. On the other hand, condensation of 6-azaindole carboxylic acid with indole 2-carboxylic acid afforded the deaza analogue ring system. Derivatives of the title ring system were tested by the National Cancer Institute (Bethesda, MD, USA) and four of them exhibited modest activity against MCF7 (a breast cancer cell line) and/or UO-31 (a renal cancer cell line).
G-PROTEIN COUPLED RECEPTOR AGONISTS
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Page/Page column 19, (2008/06/13)
Compounds of Formula (I) or pharmaceutically acceptable salts or N-oxides thereof, are agonists of GPR116 and are useful for the treatment of obesity, and for the treatment of diabetes.
PYRROLOPYRIDINE-2-CARBOXYLIC ACID AMIDE INHIBITORS OF GLYCOGEN PHOSHORYLASE
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, (2008/06/13)
Compounds represented by Formula (I): or pharmaceutically acceptable salts thereof, are inhibitors of glycogen phosphorylase and are useful in the prophylactic or therapeutic treatment of diabetes, hyperglycemia, hypercholesterolemia, hyperinsulinemia, hyperlipidemia, hypertension, atherosclerosis or tissue ischemia e.g. myocardial ischemia, and as cardioprotectants.