80076-46-6

Basic information

• Product Name: 5,6-Difluoro-1,2,3,4-tetrahydro-2-methylquinoline
• Synonyms: 5,6-Difluoro-1,2,3,4-tetrahydro-2-methylquinoline;($$+/-$$)-5,6-Difluoro-1,2,3,4-tetrahydroquinaldine;5,6-Difluoro-1,2,3,4-tetrahydro-2-methylquinoline(Nadifloxacin Intermediates)
• CAS NO: 80076-46-6
• Molecular Formula: C10H11F2N
• Molecular Weight: 183.19800
• Mol File: 80076-46-6.mol
• Article Data: 2

Chemical Properties

• Boiling Point: 247.5±40.0℃ (760 Torr)
• Flash Point: 103.5±27.3℃
• Appearance: /
• Density: 1.139±0.06 g/cm3 (20 ºC 760 Torr)
• PKA: 4.40±0.40(Predicted)
• CAS DataBase Reference: 5,6-Difluoro-1,2,3,4-tetrahydro-2-methylquinoline(CAS DataBase Reference)
• NIST Chemistry Reference: 5,6-Difluoro-1,2,3,4-tetrahydro-2-methylquinoline(80076-46-6)
• EPA Substance Registry System: 5,6-Difluoro-1,2,3,4-tetrahydro-2-methylquinoline(80076-46-6)

Safety Data

• Hazardous Substances Data: 80076-46-6(Hazardous Substances Data)

Usage

General Description

5,6-Difluoro-1,2,3,4-tetrahydro-2-methylquinoline is a chemical compound with the molecular formula C11H11F2N. It is a member of the quinoline family, which is a class of aromatic compounds often used in pharmaceuticals and agrochemicals. This specific compound contains two fluorine atoms and a methyl group attached to a quinoline ring, and is commonly used as a building block in the synthesis of various pharmaceuticals and organic molecules. It has potential applications in drug discovery, as well as in the development of new materials and chemical processes. Its unique structure and chemical properties make it a valuable tool for researchers and chemists in a variety of fields.

InChI:InChI=1S/C10H11F2N/c1-6-2-3-7-9(13-6)5-4-8(11)10(7)12/h4-6,13H,2-3H2,1H3

Upstream product

• 64695-81-4 N-(2-bromo-4,5-difluorophenyl)acetamide 
• 458-11-7 3,4-difluoroacetanilide 
• 3863-11-4 3,4-difluoroaniline 
• 131190-82-4 8-bromo-5,6-difluoro-2-methylquinoline 

Downstream Products

• 154357-40-1 9,10-difluoro-2,3-dihydro-3S-methyl-7-oxo-7H-pyrido[1,2,3-de]-1,4-benzoxazine-6-carboxylic acid 

Relevant articles and documents

Synthesis, antibacterial activities, mode of action and acute toxicity studies of new oxazolidinone-fluoroquinolone hybrids

To combat bacterial resistance, a series of new oxazolidinone-fluoroquinolone hybrids have been synthesized and characterized. All synthetic hybrids were preliminarily evaluated for their in vitro antibacterial activities against 6 standard strains and 3 clinical isolates. The majority of hybrids displayed excellent activities against Gram-positive bacteria, but limited activities against Gram-negative bacteria. Hybrids OBP-4 and OBP-5 were found to be the most promising compounds. Further, in vitro antibacterial activities, mode of action and acute toxicity in mice of hybrids OBP-4 and OBP-5 were investigated. Hybrids OBP-4 and OBP-5 exhibited potent activities against Gram-positive bacteria, including drug-resistant strains. Correspondingly, studies on the mode of action of hybrids OBP-4 and OBP-5 indicated a strong inhibitory activity on protein synthesis by binding the active site of 50S subunit, but a weak inhibitory action on DNA synthesis. In addition, LD50 values of hybrids OBP-4 and OBP-5 in the acute oral toxicity were larger than 2000 mg/kg, suggesting a good safety profile.