80122-67-4

Basic information

• Product Name: Benzene, 1-ethenyl-4-propoxy-
• CAS NO: 80122-67-4
• Molecular Formula: C11H14O
• Molecular Weight: 162.232
• Mol File: 80122-67-4.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: Benzene, 1-ethenyl-4-propoxy-(CAS DataBase Reference)
• NIST Chemistry Reference: Benzene, 1-ethenyl-4-propoxy-(80122-67-4)
• EPA Substance Registry System: Benzene, 1-ethenyl-4-propoxy-(80122-67-4)

Safety Data

• Hazardous Substances Data: 80122-67-4(Hazardous Substances Data)

Upstream product

• 1779-49-3 Methyltriphenylphosphonium bromide 
• 5736-85-6 4-propoxybenzaldehyde 
• 104174-22-3 4-propoxy-phenethyl alcohol 

Downstream Products

• 60758-84-1 4-cyanophenyl propyl ether 
• 1276021-73-8 (S)-tert-butyl 2-hydroxy-1-(4-propoxyphenyl)ethylcarbamate 
• 1276023-79-0 (S)-3-(H-imidazo[1,2-a]pyridin-7-yl)-4-(4-propoxyphenyl)oxazolidin-2-one 
• 1276023-72-3 C₁₉H₂₃N₃O₃ 
• 1276023-70-1 (S)-ethyl 2-(2-(tert-butoxycarbonylamino)-2-(4-propoxyphenyl)ethoxy)acetate 
• 1276022-88-8 C₁₂H₁₅NO₃ 
• 1276021-65-8 (S)-1-(1H-benzo[d]imidazole-5-yl)-5-(4-propoxyphenyl)imidazolidin-2-one 
• 1276021-71-6 C₂₆H₃₀N₄O₃ 
• 1276023-71-2 (S)-5-(4-propoxyphenyl)morpholin-3-one 
• 1276022-86-6 (S)-3-(1H-benzo[d]imidazol-6-yl)-4-(4-propoxyphenyl)oxazolidin-2-one 
• 1276021-70-5 (S)-1-(4-methoxybenzyl)-4-(4-propoxyphenyl)imidazolidin-2-one 
• 354809-93-1 8-chloro-4-(4-propoxyphenyl)-1,2,3,4-tetrahydroquinoline-2-carboxylic acid 
• 643027-88-7 1,3,5-tris[(diethoxyphosphoryl)methyl]-2,4,6-tris[(E)-2-(4-propoxyphenyl)ethenyl]benzene 
• 643027-87-6 1,3,5-trimethyl-2,4,6-tris[(E)-2-(4-propoxyphenyl)ethenyl]benzene 

Relevant articles and documents

Design, synthesis of novel 4,5-dihydroisoxazole-containing benzamide derivatives as highly potent FtsZ inhibitors capable of killing a variety of MDR Staphylococcus aureus

Antibiotic resistance among clinically significant bacterial pathogens, such as methicillin-resistant Staphylococcus aureus (MRSA) and vancomycin-resistant S. aureus (VRSA) is becoming a prevalent threat to public health, and new antibacterial agents with novel mechanisms of action hence are in an urgent need. As a part of continuing effort to develop antibacterial agents, we rationally designed and synthesized two series of 4,5-dihydroisoxazol-5-yl and 4,5-dihydroisoxazol-3-yl-containing benzamide derivatives that targeted the bacterial cell division protein FtsZ. Evaluation of their activity against a panel of Gram-positive and -negative pathogens revealed that compound A16 possessing the 4,5-dihydroisoxazol-5-yl group showed outstanding antibacterial activity (MIC, ≤0.125–0.5 μg/mL) against various testing strains, including methicillin-resistant, penicillin-resistant and clinical isolated S. aureus strains. Besides, further mouse infection model revealed that A16 could be effective in vivo and non-toxic to Hela cells. Finally, a detailed discussion of structure-activity relationships was conducted, referring to the docking results. It is worth noting that substituting a 4,5-dihydroisoxazole ring for the isoxazole ring not only broadened the antibacterial spectrum but also resulted in a significant increase in antibacterial activity against S. aureus strains. Taken together, these results suggest a promising chemotype for the development of new FtsZ-targeting bactericidal agents.

Alkoxy-Substituted Hexastyrylbenzenes

Star-shaped compounds 2a - e with a central benzene ring and six p-substituted, (E)-configured styryl groups have been prepared by a sequence of three-fold Heck and three-fold Wittig-Horner reactions. Alkoxy chains (OC 3H7, OC6