80141-50-0 Usage
Description
(R)-3-chloro-2-methylpropanoyl chloride, with the molecular formula C4H6Cl2O, is a colorless to pale yellow liquid chemical compound. It serves as a reagent in organic synthesis and is a source of the (R)-3-chloro-2-methylpropanoate anion, which is utilized as a chiral building block in the synthesis of various products, including pharmaceuticals, agrochemicals, and fine chemicals.
Uses
Used in Pharmaceutical Synthesis:
(R)-3-chloro-2-methylpropanoyl chloride is used as a chiral building block for the synthesis of pharmaceuticals, contributing to the development of new drugs with improved efficacy and selectivity.
Used in Agrochemical Production:
In the agrochemical industry, (R)-3-chloro-2-methylpropanoyl chloride is employed as a key intermediate in the production of various agrochemicals, enhancing the effectiveness of these products in agriculture.
Used in Fine Chemicals Synthesis:
(R)-3-chloro-2-methylpropanoyl chloride is also utilized in the synthesis of fine chemicals, where its chiral nature allows for the creation of enantiomerically pure compounds with specific applications.
Used in Ester and Amide Preparation:
(R)-3-chloro-2-methylpropanoyl chloride is used in the preparation of various esters and amides, which are essential in a range of chemical reactions and applications.
Safety Precautions:
Due to its high reactivity and potential hazards, (R)-3-chloro-2-methylpropanoyl chloride must be handled with care to avoid irritant properties and ensure safe laboratory practices.
Check Digit Verification of cas no
The CAS Registry Mumber 80141-50-0 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 8,0,1,4 and 1 respectively; the second part has 2 digits, 5 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 80141-50:
(7*8)+(6*0)+(5*1)+(4*4)+(3*1)+(2*5)+(1*0)=90
90 % 10 = 0
So 80141-50-0 is a valid CAS Registry Number.
80141-50-0Relevant articles and documents
Chemoenzymatic Synthesis in Flow Reactors: A Rapid and Convenient Preparation of Captopril
De Vitis, Valerio,Dall'Oglio, Federica,Pinto, Andrea,De Micheli, Carlo,Molinari, Francesco,Conti, Paola,Romano, Diego,Tamborini, Lucia
, p. 668 - 673 (2017/09/06)
The chemoenzymatic flow synthesis of enantiomerically pure captopril, a widely used antihypertensive drug, is accomplished starting from simple, inexpensive, and readily available reagents. The first step is a heterogeneous biocatalyzed regio- and stereoselective oxidation of cheap prochiral 2-methyl-1,3-propandiol, performed in flow using immobilized whole cells of Acetobacter aceti MIM 2000/28, thus avoiding the use of aggressive and environmentally harmful chemical oxidants. The isolation of the highly hydrophilic intermediate (R)-3-hydroxy-2-methylpropanoic acid is achieved in-line by using a catch-and-release strategy. Then, three sequential high-throughput chemical steps lead to the isolation of captopril in only 75 min. In-line quenching and liquid–liquid separation enable breaks in the workflow and other manipulations to be avoided.
