80166-01-4Relevant articles and documents
Discovery of a new class of multi-target heterocycle piperidine derivatives as potential antipsychotics with pro-cognitive effect
Gao, Lanchang,Hao, Chao,Chen, Jiali,Ma, Ru,Zheng, Lu,Wu, Qingkun,Liu, Xin,Liu, Bi-Feng,Zhang, Guisen,Chen, Yin,Jin, Jian
supporting information, (2021/03/19)
A series of benzoisoxazoleylpiperidine derivatives were synthesized by using the multi-target strategies and their potent affinities for dopamine (DA), serotonin (5-HT) and human histamine H3 receptors have been evaluated. Of these compounds, t
Synthesis and biological evaluation of a new class of multi-target heterocycle piperazine derivatives as potential antipsychotics
Gao, Lanchang,Hao, Chao,Ma, Ru,Chen, Jiali,Zhang, Guisen,Chen, Yin
, p. 16931 - 16941 (2021/05/25)
In this study, we designed and synthesized a novel series of multi-receptor ligands as polypharmacological antipsychotic agents by using a multi-receptor affinity strategy. Among them,3wcombines a multi-receptor mechanism with high mixed affinities for D
FUSED THIOPHENE COMPOUNDS
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Paragraph 0129; 0138, (2020/01/08)
The present disclosure provides compounds that modulate protein function of 1 L-1β, IL-2, IL-6, TNF-α, CK1α, GSPT1, aiolos, ikaros or helios, to restore protein homeostasis, and 1 cell-cell adhesion. The disclosure provides methods of modulating protein-mediated diseases, such as cytokine-mediated diseases, disorders, conditions, or responses. Compositions, including in combination with other cytokine and inflammatory mediators are provided. Uses of compounds for treatment or amelioration of diseases, disorders, or conditions associated with a protein, are also provided.