80174-70-5

Basic information

• Product Name: Z-Phe-Leu-Phe-Phe-OBzl
• Synonyms: Z-Phe-Leu-Phe-Phe-OBzl
• CAS NO: 80174-70-5
• Molecular Weight: 796.963
• Mol File: 80174-70-5.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: Z-Phe-Leu-Phe-Phe-OBzl(CAS DataBase Reference)
• NIST Chemistry Reference: Z-Phe-Leu-Phe-Phe-OBzl(80174-70-5)
• EPA Substance Registry System: Z-Phe-Leu-Phe-Phe-OBzl(80174-70-5)

Safety Data

• Hazardous Substances Data: 80174-70-5(Hazardous Substances Data)

Upstream product

• 70363-50-7 Z-Phe-Leu-OTMB 
• 4313-73-9 N-[N-[(phenylmethoxy)carbonyl]-L-phenylalanyl]-L-leucine 
• 2462-32-0 L-phenylalanine benzyl ester hydrochloride 

Relevant articles and documents

ENZYMIC SYNTHESIS OF OLIGOPETIDE - VI. THE MECHANISTIC FEATURES OF PEPSIN-CATALYSED PEPTIDE SYNTHESIS

The dipeptide Z-Phe-Phe-OBzl and tripeptide Z-Phe-Phe-Phe-OBzl were synthesized by pepsin catalysis from the incubation of Z-Phe and Phe-OBzl in the reaction solution.The yield ratio of two peptides in relation to reaction time was investigated by HPLC.Another example: The tripeptide Z-Phe-Leu-Phe-OBzl and tetrapeptide Z-Phe-Leu-Phe-Phe-OBzl were also synthesized concurrently from Z-Phe-Leu and Phe-OBzl by pepsin catalysis.These results may have important implication for the transpeptidation of pepsin.But, according to the report of Pellegrini and Luisi, the dipeptide, Z-Ph-Phe-OBzl, synthesized by pepsin catalysis was not contaminated with the tripeptide,Z-Phe-Phe-Phe-OBzl, and the yield was high.In order to investigate the discrepancies between our observation and those reported by Pellegrini and Luisi, a mechanism by which pepsin synthesizes the dipeptide, Z-Phe-Phe-OBzl, and tripeptide, Z-Phe-Phe-Phe-OBzl, is proposed and supporting data demonstrated by HPLC analysis.