80189-44-2 Usage
Description
1-Hydroxy-5,8-bis(2-((2-hydroxyethyl)amino)ethylamino)-9,10-anthracenedione is a complex organic compound with a unique molecular structure. It is characterized by the presence of hydroxy and amino groups, which contribute to its chemical properties and potential applications.
Uses
Used in Pharmaceutical Industry:
1-Hydroxy-5,8-bis(2-((2-hydroxyethyl)amino)ethylamino)-9,10-anthracenedione is used as an impurity in the production of Mitoxantrone (M373425), a DNA intercalating drug. Mitoxantrone is employed as an anti-cancer agent, specifically for the treatment of various types of cancer. It works by inhibiting DNA synthesis, thereby preventing the growth and proliferation of cancer cells.
As an impurity in Mitoxantrone, 1-hydroxy-5,8-bis(2-((2-hydroxyethyl)amino)ethylamino)-9,10-anthracenedione may have potential implications for the drug's efficacy and safety. Further research and development may be necessary to fully understand its role and impact on the overall performance of Mitoxantrone as an anti-cancer agent.
Check Digit Verification of cas no
The CAS Registry Mumber 80189-44-2 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 8,0,1,8 and 9 respectively; the second part has 2 digits, 4 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 80189-44:
(7*8)+(6*0)+(5*1)+(4*8)+(3*9)+(2*4)+(1*4)=132
132 % 10 = 2
So 80189-44-2 is a valid CAS Registry Number.
InChI:InChI=1/C22H28N4O5/c27-12-10-23-6-8-25-15-4-5-16(26-9-7-24-11-13-28)20-19(15)21(30)14-2-1-3-17(29)18(14)22(20)31/h1-5,23-29H,6-13H2
80189-44-2Relevant articles and documents
Antiproliferative activity of doxorubicin and aminoanthraquinone derivatives on Chinese hamster ovary cells
Uyeki,Nishio,Wittek,Cheng
, p. 1011 - 1014 (2007/10/02)
A study of the antiproliferative activity of doxorubicin and several substituted aminoanthraquinone derivatives on Chinese hamster ovary cells was conducted. Doxorubicin and a derivative each inhibited cell prliferation at low concentrations, the latter being more potent than doxorubicin. A structure-activity relationship of these compounds is discussed in connection with an earlier postulated N-O-O triangulation hypothesis.
