80278-67-7

Basic information

• Product Name: ISOQUINOLINE-5-CARBALDEHYDE
• Synonyms: RARECHEM AK ML 0044;CHEMBRDG-BB 4301909;ISOQUINOLINE-5-CARBOXALDEHYDE;ISOQUINOLINE-5-CARBALDEHYDE;Isoquinoline-5-carboxaldehyde,97%;5-Isoquinolinecarboxaldehyde (6CI,9CI);5-isoquinolinecarboxaldehyde;5-Formyl isoquinoline
• CAS NO: 80278-67-7
• Molecular Formula: C₁₀H₇NO
• Molecular Weight: 157.17
• EINECS: -0
• Product Categories: ALDEHYDE;Isoquinoline Derivertives;Building Blocks;Isoquinoline;Building Blocks;Heterocyclic Building Blocks;Isoquinolines
• Mol File: 80278-67-7.mol
• Article Data: 7

Chemical Properties

• Melting Point: 113-116°C
• Boiling Point: 331.718 °C at 760 mmHg
• Flash Point: 162.428 °C
• Appearance: /
• Density: 1.224 g/cm³
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.687
• Storage Temp.: Keep in dark place,Sealed in dry,Room Temperature
• PKA: 4.53±0.13(Predicted)
• Sensitive: Air Sensitive
• BRN: 112875
• CAS DataBase Reference: ISOQUINOLINE-5-CARBALDEHYDE(CAS DataBase Reference)
• NIST Chemistry Reference: ISOQUINOLINE-5-CARBALDEHYDE(80278-67-7)
• EPA Substance Registry System: ISOQUINOLINE-5-CARBALDEHYDE(80278-67-7)

Safety Data

• Hazard Codes: Xn
• Statements: 36/37/38-36-22
• Safety Statements: 26-36
• WGK Germany: 3
• HazardClass: IRRITANT
• Hazardous Substances Data: 80278-67-7(Hazardous Substances Data)

Usage

Uses

Direct conversion of heteroaryl-carboxaldehydes to acetonitriles by treatment with cyanoethylphosphonate followed by samarium(II) iodide reduction.

InChI:InChI=1/C10H7NO/c12-7-9-3-1-2-8-6-11-5-4-10(8)9/h1-7H

Upstream product

• 62882-01-3 5-methylisoquinoline 
• 16675-59-5 methyl isoquinoline-5-carboxylate 
• 34784-04-8 5-bromoisoquinoline 
• 68-12-2 N,N-dimethyl-formamide 
• 119-65-3 isoquinoline 
• 100643-54-7 5-methyl-3,4-dihydro-isoquinoline 
• 857822-30-1 2-(2-methylphenyl)ethylformamide 
• 1532-71-4 1-bromoisoquinoline 

Downstream Products

• 1260094-61-8 (Z)-5-(3-(N,N-dibutylamino)styryl)isoquinoline 
• 1260094-60-7 (E)-5-(3-(N,N-dibutylamino)styryl)isoquinoline 
• 54415-44-0 1-isoquinolin-5-yl-ethanone 
• 158654-74-1 5-(bromomethyl)isoquinoline 
• 119-65-3 isoquinoline 
• 16675-59-5 methyl isoquinoline-5-carboxylate 

Relevant articles and documents

PROCESS FOR PREPARING A COT INHIBITOR COMPOUND

Disclosed are syntheses of a Cot (cancer Osaka thyroid) inhibitor, which has the formula (I).

Co-administration of dopamine-receptor binding compounds

Methods for treating a patient having neurological, psychotic, and psychiatric disorders are described comprising the steps of administering to the patient an effective amount of a partial and/or full dopamine D1 receptor agonist, and administering to the patient an effective amount of a dopamine D2 receptor antagonist. Pharmaceutical compositions comprising a dopamine D1 receptor agonist and a dopamine D2 receptor antagonist are also described. The D1 dopamine receptor agonist and the D2 dopamine receptor antagonist can be administered to the patient in the same or in a different composition or compositions.

Process for the preparation of dinaposoline

The present invention relates to a novel process for the preparation of compounds of the formula wherein R1, R2, R4, R5, R6and A are as defined herein, and to certain derivations of Formula IX which are useful for the treatment of movement disorders.