802916-50-3

Basic information

• Product Name: 5-Pyrimidinecarboxylic acid, 1,4-dihydro-2-[methyl(phenylmethyl)amino]-4-oxo-, ethyl ester
• CAS NO: 802916-50-3
• Molecular Formula: C15H17N3O3
• Molecular Weight: 287.318
• Mol File: 802916-50-3.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 5-Pyrimidinecarboxylic acid, 1,4-dihydro-2-[methyl(phenylmethyl)amino]-4-oxo-, ethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 5-Pyrimidinecarboxylic acid, 1,4-dihydro-2-[methyl(phenylmethyl)amino]-4-oxo-, ethyl ester(802916-50-3)
• EPA Substance Registry System: 5-Pyrimidinecarboxylic acid, 1,4-dihydro-2-[methyl(phenylmethyl)amino]-4-oxo-, ethyl ester(802916-50-3)

Safety Data

• Hazardous Substances Data: 802916-50-3(Hazardous Substances Data)

Upstream product

• 40516-46-9 diethyl (ethoxymethylene)malonate 
• 330-69-8 N-benzyl-N-methylguanidine hydrochloride 
• 87-13-8 diethyl 2-ethoxymethylenemalonate 

Downstream Products

• 802916-51-4 C₁₃H₁₃N₃O₃ 

Relevant articles and documents

Discovery and structure-activity relationships of trisubstituted pyrimidines/pyridines as novel calcium-sensing receptor antagonists

The trisubstituted pyrimidine 1 was identified through high-throughput screening as a novel calcium-sensing receptor (CaSR) antagonist. Small molecule CaSR antagonists and/or negative allosteric modulators have the potential to act as an anabolic agent for the treatment of osteoporosis. The investigation of structure-activity relationships around 1 resulted in the identification of 18c and 18d, which showed efficacy at promoting PTH release in vivo and exhibited improved potency and solubility over the original lead 1.