80304-54-7

Basic information

• Product Name: 1-BROMO-2-ISOBUTYLBENZENE
• Synonyms: 1-(2-Methylpropyl)-2-bromobenzene;1-Bromo-2-(2-methylpropyl)benzene;2-Isobutylphenylbromide;Benzene,1-bromo-2-(2-methylpropyl)-;Benzene,1-bromo-2-isobutyl-;o-bromoisobutylbenzene;1-BROMO-2-ISOBUTYLBENZENE
• CAS NO: 80304-54-7
• Molecular Formula: C₁₀H₁₃Br
• Molecular Weight: 213.11
• Mol File: 80304-54-7.mol
• Article Data: 5

Chemical Properties

• Melting Point: -47.30 °C
• Boiling Point: 233.0±9.0 °C(Predicted)
• Appearance: /
• Density: 1.2476 g/cm3
• CAS DataBase Reference: 1-BROMO-2-ISOBUTYLBENZENE(CAS DataBase Reference)
• NIST Chemistry Reference: 1-BROMO-2-ISOBUTYLBENZENE(80304-54-7)
• EPA Substance Registry System: 1-BROMO-2-ISOBUTYLBENZENE(80304-54-7)

Safety Data

• Hazardous Substances Data: 80304-54-7(Hazardous Substances Data)

Usage

Physical State

Colorless to pale yellow liquid

Odor

Strong, sweet aromatic

Uses

a. Intermediate in the synthesis of pharmaceuticals
b. Intermediate in the synthesis of agrochemicals
c. Intermediate in the synthesis of various organic compounds
d. Solvent in chemical reactions

Health Hazards

a. Flammability
b. Harmful if swallowed
c. Harmful if inhaled
d. Harmful if absorbed through the skin

Safety Precautions

Handle with caution and in accordance with proper safety procedures and regulations.

Upstream product

• 538-93-2 1-phenyl-2-methylpropane 
• 2307-69-9 toluene-4-sulfonic acid isopropyl ester 
• 3433-80-5 1-Bromo-2-bromomethyl-benzene 
• 91388-25-9 1-bromo-2-(2-methylprop-1-en-1-yl)benzene 
• 6630-33-7 ortho-bromobenzaldehyde 
• 71182-59-7 2-isobutylaniline 
• 615-36-1 2-bromoaniline 

Downstream Products

• 1651220-48-2 (2-isobutylphenyl)boronic acid 
• 102759-13-7 <2-Isobutyl-benzhydryl>-<2-dimethylamino-aethyl>-aether 
• 109398-00-7 2-Isobutyl-benzhydrol 

Relevant articles and documents

Exploiting the Biginelli reaction: Nitrogen-rich pyrimidine-based tercyclic α-helix mimetics

Several rationally designed pyrimidine-based scaffolds intended to mimic the spatial projection of the i, i+3, and i+7 residues of an α-helix and also possess improved aqueous solubility were prepared. A Biginelli-oxidation process was used to form the central pyrimidine ring of these scaffolds, which was subsequently manipulated to form pyrimidine-based tercyclic α-helix mimetics. A pyrimidine-based scaffold designed to mimic the α-helical BH3 domain of the pro-apoptotic Bak protein was also prepared as a putative inhibitor of the Bcl-xL/Bak protein-protein interaction. The pyrimidine-based tercyclic α-helix mimetics, and the putative Bcl-xL inhibitor, were assessed using a luminescence competition assay, however, none displayed inhibitory activity against Bcl-xL or Mcl-1.

Bromination of aromatic compounds using ammonium bromide and oxone

A simple, efficient and mild method for the selective bromination of activated aromatic compounds using ammonium bromide as the source of bromine and Oxone as the oxidant in methanol or water as solvent is reported. The reaction proceeds at ambient temperature in yields ranging from moderate to excellent without a catalyst. Georg Thieme Verlag Stuttgart.

The effects of alkyl substitution in drugs-I. Substituted dimethylaminoethyl benzhydryl ethers.

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