80306-55-4

Basic information

• Product Name: 3-(2-methylphenyl)-2-(methylsulfanyl)pyrimidin-4(3H)-one
• Synonyms: 4(3H)-pyrimidinone, 3-(2-methylphenyl)-2-(methylthio)-
• CAS NO: 80306-55-4
• Molecular Formula: C₁₂H₁₂N₂OS
• Molecular Weight: 232.3015
• Mol File: 80306-55-4.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 363.2°C at 760 mmHg
• Flash Point: 173.5°C
• Density: 1.19g/cm³
• Vapor Pressure: 1.83E-05mmHg at 25°C
• Refractive Index: 1.617
• CAS DataBase Reference: 3-(2-methylphenyl)-2-(methylsulfanyl)pyrimidin-4(3H)-one(CAS DataBase Reference)
• NIST Chemistry Reference: 3-(2-methylphenyl)-2-(methylsulfanyl)pyrimidin-4(3H)-one(80306-55-4)
• EPA Substance Registry System: 3-(2-methylphenyl)-2-(methylsulfanyl)pyrimidin-4(3H)-one(80306-55-4)

Safety Data

• Hazardous Substances Data: 80306-55-4(Hazardous Substances Data)

Upstream product

• 4949-88-6 N-benzoyl-N'-(2-methylphenyl)thiourea 
• 80306-60-1 N-(2-methylphenyl)-S-methylisothiourea 
• 82636-16-6 Ethyl 3-(2'-methylphenyl)-2-methylmercapto-4-(3H)pyrimidone-5-carboxylate 
• 95-53-4 o-toluidine 
• 614-78-8 o-tolylthiourea 
• 623-47-2 propynoic acid ethyl ester 
• 82636-27-9 3-(2'-Methylphenyl)-2-methylmercapto-4-(3H)pyrimidone-5-carboxylic acid 

Relevant articles and documents

Synthesis and Biological Activity of 2,6-disubstituted 3-Aryl-4(3H)-pyrimidones as Potential CNS Agents

The reaction of N-arylamidines (III) with appropriate 2-alkynoic ester gives 2,6-disubstituted 3-aryl-4(3H)-pyrimidones (IV) in one step except in the reaction of N-(2-trifluoromethylphenyl/biphenyl)-S-methylisothiourea with ethyl propiolate, where the required pyrimidones (IVa17/IVa20) along with the adduct (Va/Vb) have been isolated; these adducts on cyclisation yield the corresponding pyrimidinones (IVa17/IVa20). 2,3,6-Triphenyl-4(3H)-pyrimidone (IVh1) on treatment with P2S5 furnishes the corresponding thione (VI).Some of these compounds have shown significant central muscle relaxant, hypnotic, anticonvulsant, CNS depressant, antiinflammatory and diuretic activities.

A convenient method for the synthesis of 2,6-disubstituted 3-aryl-4(3H)-pyrimidones

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