80317-46-0Relevant articles and documents
Highly Regio- And Enantioselective Reductive Coupling of Alkynes and Aldehydes via Photoredox Cobalt Dual Catalysis
Li, Yan-Lin,Zhang, Shi-Qi,Chen, Jie,Xia, Ji-Bao
supporting information, p. 7306 - 7313 (2021/05/26)
A Co-catalyzed highly regio- and enantioselective reductive coupling of alkynes and aldehydes has been developed under visible light photoredox dual catalysis. A variety of enantioenriched allylic alcohols have been obtained by using unsymmetrical internal alkynes and commercially available catalyst, chiral ligand, and reagents. It is noteworthy that this approach has considerable advantages, such as excellent regio- (>95:5 for >40 examples), stereo- (up to >95:5 E/Z), and enantioselectivity (92-99% ee, >35 examples) control, mild reaction conditions, broad substrate scope, and good functional group compatibility, making it a great improvement to enantioselective alkyne-aldehyde reductive coupling reactions.
Direct vinylation of alcohols or aldehydes employing alkynes as vinyl donors: A ruthenium catalyzed C-C bond-forming transfer hydrogenation
Patman, Ryan L.,Chaulagain, Mani Raj,Williams, Vanessa M.,Krische, Michael J.
supporting information; experimental part, p. 2066 - 2067 (2009/07/30)
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Episulfone substitution and ring-opening reactions via α-sulfonyl carbanion intermediates
Dishington, Allan P.,Douthwaite, Richard E.,Mortlock, Andrew,Muccioli, Adriano B.,Simpkins, Nigel S.
, p. 323 - 337 (2007/10/03)
Three-membered cyclic sulfones undergo substitution on treatment with base-electrophile mixtures, such as LDA-Me3SiCl and Bu′-P4 phosphazene base-PhCHO, to give either substituted episulfones or the corresponding alkenes following loss of SO2. The structure of a trisilylated episulfone product, 2a, was determined by X-ray crystallography. In the absence of Me3SiCl, reaction of episulfones with lithium diisopropylamide results in ring-opening to give alkenyl sulfinate intermediates, which can be alkylated to give (E)-alkenyl sulfone products in stereoselective fashion.