80446-60-2

Basic information

• Product Name: (S)-4-methyl-α-(trifluoromethyl)-benzenemethanol
• Synonyms: (S)-4-methyl-α-(trifluoromethyl)-benzenemethanol
• CAS NO: 80446-60-2
• Molecular Weight: 190.165
• Mol File: 80446-60-2.mol
• Article Data: 11

Chemical Properties

• CAS DataBase Reference: (S)-4-methyl-α-(trifluoromethyl)-benzenemethanol(CAS DataBase Reference)
• NIST Chemistry Reference: (S)-4-methyl-α-(trifluoromethyl)-benzenemethanol(80446-60-2)
• EPA Substance Registry System: (S)-4-methyl-α-(trifluoromethyl)-benzenemethanol(80446-60-2)

Safety Data

• Hazardous Substances Data: 80446-60-2(Hazardous Substances Data)

Upstream product

• 446-65-1 2,2,2-trifluoro-1-(4-methylphenyl)ethanol 
• 97-72-3 2-Methylpropionic anhydride 
• 394-59-2 2,2,2-trifluoro-1-(p-tolyl)ethanone 
• 104-87-0 4-methyl-benzaldehyde 
• 81290-20-2 (trifluoromethyl)trimethylsilane 

Relevant articles and documents

Asymmetric Hydrogenation of Aryl Perfluoroalkyl Ketones Catalyzed by Rhodium(III) Monohydride Complexes Bearing Josiphos Ligands

The asymmetric hydrogenation of 2,2,2-trifluoroacetophenones and aryl perfluoroalkyl ketones was developed using a unique, well-defined chloride-bridged dinuclear rhodium(III) complex bearing Josiphos-type diphosphine ligands. These complexes were prepared from [RhCl(cod)]2, Josiphos ligands, and hydrochloric acid. As catalyst precursors, they allow for the efficient and enantioselective synthesis (up to 99 % ee) of chiral secondary alcohols with perfluoroalkyl groups. This system does not require an activating base for the hydrogenation of 2,2,2-trifluoroacetophenones. Additionally, the enantioselective C=O hydrogenations of 2-phenyl-3-(haloacetyl)-indoles, a class of privileged structures in medicinal chemistry, is reported for the first time.

Cinchona alkaloid/TMAF combination: Enantioselective trifluoromethylation of aryl aldehydes

The catalytic enantioselective trifluoromethylation reaction of aromatic aldehydes using the Ruppert-Prakash reagent (Me3SiCF3) has been disclosed, with an operationally simple procedure, based on the combination of sterically demand

Asymmetric trifluoromethylation of aromatic aldehydes by cooperative catalysis with (IPr)CuF and quinidine-derived quaternary ammonium salt

A general enantioselective trifluoromethylation of aldehydes has been developed using (IPr)CuF and quinidine-derived quaternary ammonium salt as the cooperative catalyst. Thus, a wide range of aromatic aldehydes have been converted to the corresponding products in up to 92% yield and 81% ee at 2 mol% of catalyst loading. The greatly enhanced activity and enantioselectivity result from the initiative generation of active [(IPr)CuCF3] as well as additional coordination activation of other copper species.