80457-65-4

Basic information

• Product Name: ethyl 2-(3,5-bisbenzyloxyphenyl)-2-methoxycarbonylacetate
• Synonyms: ethyl 2-(3,5-bisbenzyloxyphenyl)-2-methoxycarbonylacetate
• CAS NO: 80457-65-4
• Molecular Weight: 434.489
• Mol File: 80457-65-4.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: ethyl 2-(3,5-bisbenzyloxyphenyl)-2-methoxycarbonylacetate(CAS DataBase Reference)
• NIST Chemistry Reference: ethyl 2-(3,5-bisbenzyloxyphenyl)-2-methoxycarbonylacetate(80457-65-4)
• EPA Substance Registry System: ethyl 2-(3,5-bisbenzyloxyphenyl)-2-methoxycarbonylacetate(80457-65-4)

Safety Data

• Hazardous Substances Data: 80457-65-4(Hazardous Substances Data)

Upstream product

• 80457-61-0 methanesulfonyl 3,5-dibenzyloxybenzyl alcohol 
• 58604-84-5 (3',5'-dibenzyloxy)phenylacetonitrile 
• 2732-96-9 3,5-dibenzyloxyphenylacetic acid 
• 24131-31-5 3,5-dibenzyloxybenzyl alcohol 
• 99-10-5 3,5-Dihydroxybenzoic acid 
• 58605-10-0 methyl 3,5-bis(benzyloxy)benzoate 
• 4724-10-1 methyl 2-(3,5-dihydroxyphenyl)acetate 
• 2150-44-9 1-carbomethoxy-3,5-dihydroxybenzene 

Downstream Products

• 80457-68-7 2-(3,5-bisbenzyloxyphenyl)pent-2-ynoic acid 
• 80457-67-6 ethyl methyl 3,5-bisbenzyloxyphenyl(prop-2-ynyl)malonate 

Relevant articles and documents

Drugs derived from Cannabinoids. Part 8. The Synthesis of Side-chain Analogues of Δ6a,10a-Tetrahydrocannabinol

The continuation of studies on the synthesis of side-chain analogues of Δ6a,10a-tetrahydrocannabinol as potential therapeutic agents has led to the syntheses of a possible metabolite 1-hydroxy-6,6,9-trimethyl-7,8,9,10-tetrahydro-6H-dibenzopyran-3-ylacetic acid (1) and 2-(1-hydroxy-6,6,9-trimethyl-7,8,9,10-tetrahydro-6H-dibenzopyran-3-yl)pent-4-ynoic acid (17c).The Pechmann condensation of ethyl 4-methyl-2-oxocyclohexane-1-carboxylate with methyl 3,5-dihydroxyphenylacetate (11), followed by Grignard reaction, was utilized to produce the pyran (1).The key step in the synthesis of the propargylacetic acid (17c) was propargylation of the malonate (15) under phase-transfer catalysis.