80501-45-7

Basic information

• Product Name: Cyclopentanecarbonitrile, 2-amino- (9CI)
• Synonyms: Cyclopentanecarbonitrile, 2-amino- (9CI);2-aminocyclopentanecarbonitrile;2-aocyclopentanecarbonitrile
• CAS NO: 80501-45-7
• Molecular Formula: C₆H₁₀N₂
• Molecular Weight: 110.157
• Product Categories: VARIOUSAMINE
• Mol File: 80501-45-7.mol
• Article Data: 4

Chemical Properties

• Melting Point: 147 °C
• Boiling Point: 225.4±33.0 °C(Predicted)
• Appearance: /
• Density: 1.02±0.1 g/cm3(Predicted)
• Storage Temp.: 2-8°C
• PKA: 9.47±0.40(Predicted)
• CAS DataBase Reference: Cyclopentanecarbonitrile, 2-amino- (9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: Cyclopentanecarbonitrile, 2-amino- (9CI)(80501-45-7)
• EPA Substance Registry System: Cyclopentanecarbonitrile, 2-amino- (9CI)(80501-45-7)

Safety Data

• Hazardous Substances Data: 80501-45-7(Hazardous Substances Data)

Usage

Description

Cyclopentanecarbonitrile, 2-amino(9CI) is a colorless liquid chemical compound with the molecular formula C6H9N. It is a versatile building block in the synthesis of various pharmaceuticals and agrochemicals, particularly in the production of pesticides, insecticides, and other nitrogen-containing organic compounds.

Uses

Used in Pharmaceutical Industry:
Cyclopentanecarbonitrile, 2-amino(9CI) is used as a key intermediate in the synthesis of certain pharmaceutical compounds. Its unique structure allows for the development of new drugs with potential therapeutic applications.
Used in Agrochemical Industry:
Cyclopentanecarbonitrile, 2-amino(9CI) is used as a precursor in the production of various agrochemicals, including pesticides and insecticides. Its ability to form nitrogen-containing organic compounds makes it an essential component in the development of effective and environmentally friendly agricultural products.
Used in Organic Chemistry Research:
Cyclopentanecarbonitrile, 2-amino(9CI) is also used as a starting material in the synthesis of other nitrogen-containing organic compounds, contributing to the advancement of organic chemistry and the discovery of new chemical entities with potential applications in various industries.

Upstream product

• 111-69-3 hexanedinitrile 
• 2321-76-8 2-iminocyclopentanecarbonitrile 
• 2941-23-3 2-amino-1-cyanocyclopentene 

Downstream Products

• 21544-02-5 2-(aminomethyl)-cyclopentylamine 
• 924669-64-7 2-((6-chloropyridin-3-yl)methylamino)cyclopentanecarbonitrile 
• 1418199-98-0 trans-2-[6-benzenesulfonyl-2-((R)-1-hydroxy-ethyl)-6H-1,3,5,6-tetraaza-as-indacen-1-yl]-cyclopentanecarbonitrile 

Relevant articles and documents

FUSED TRICYCLIC COMPOUNDS FOR USE AS INHIBITORS OF JANUS KINASES

The invention provides novel compounds of formula (I) having the general formula (I) wherein R1, V, W, X, Y and Z are as described herein. Accordingly, the compounds may be provided in pharmaceutically acceptable compositions and used for the treatment of immunological or hyperproliferative disorders.

Synthesis and microbial transformation of β-amino nitriles

Rhodococcus equi A4, Rhodococcus erythropolis NCIMB 11540 and Rhodococcus sp. R312 were investigated towards their ability to produce β-amino amides and acids from β-amino nitriles. The microorganisms show comparable trends: five-membered alicyclic 2-amino nitriles were transformed significantly faster than the six-membered compounds and the products of trans-2-amino nitriles (amides and acids) were formed considerably faster than the cis-counterparts (amides). The trans-five membered nitriles gave the amides (1b, 5b) in excellent enantiomeric excess (94-99%), the biotransformation of trans-six membered substrates resulted in the formation of the acid (3c, 7c) in excellent ee (87-99%). The ee's of the cis-compounds were throughout lower. Fifteen new substances were synthesized and characterized in the course of this work.