805241-63-8

Basic information

• Product Name: 1,3-Dioxane-4-acetic acid, 6-[2-[2-(4-fluorophenyl)-4-[[[4-(hydroxymethyl)phenyl]amino]carbonyl]-5-( 1-methylethyl)-3-phenyl-1H-pyrrol-1-yl]ethyl]-2,2-dimethyl-, 1,1-dimethylethyl ester, (4R,6R)-
• CAS NO: 805241-63-8
• Molecular Formula: C41H49FN2O6
• Molecular Weight: 684.848
• Mol File: 805241-63-8.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: 1,3-Dioxane-4-acetic acid, 6-[2-[2-(4-fluorophenyl)-4-[[[4-(hydroxymethyl)phenyl]amino]carbonyl]-5-( 1-methylethyl)-3-phenyl-1H-pyrrol-1-yl]ethyl]-2,2-dimethyl-, 1,1-dimethylethyl ester, (4R,6R)-(CAS DataBase Reference)
• NIST Chemistry Reference: 1,3-Dioxane-4-acetic acid, 6-[2-[2-(4-fluorophenyl)-4-[[[4-(hydroxymethyl)phenyl]amino]carbonyl]-5-( 1-methylethyl)-3-phenyl-1H-pyrrol-1-yl]ethyl]-2,2-dimethyl-, 1,1-dimethylethyl ester, (4R,6R)-(805241-63-8)
• EPA Substance Registry System: 1,3-Dioxane-4-acetic acid, 6-[2-[2-(4-fluorophenyl)-4-[[[4-(hydroxymethyl)phenyl]amino]carbonyl]-5-( 1-methylethyl)-3-phenyl-1H-pyrrol-1-yl]ethyl]-2,2-dimethyl-, 1,1-dimethylethyl ester, (4R,6R)-(805241-63-8)

Safety Data

• Hazardous Substances Data: 805241-63-8(Hazardous Substances Data)

Upstream product

• 936847-59-5 methyl 4-(4-methyl-3-oxopentanamido)benzoate 
• 619-45-4 4-methoxycarbonyl aniline 
• 150-13-0 4-amino-benzoic acid 
• 62148-67-8 2-chloro-1-(4-fluorophenyl)-2-phenylethan-1-one 
• 936847-61-9 methyl 4-(2-(2-(4-fluorophenyl)-2-oxo-1-phenylethyl)-4-methyl-3-oxopentanamido)benzoate 
• 619-73-8 4-nitrobenzyl chloride 
• 39834-49-6 (((4-nitrobenzyl)oxy)methanetriyl)tribenzene 
• 103-80-0 phenylacetyl chloride 
• 125971-86-0 tert-butyl [(4R,6R)-6-aminoethyl-2,2-dimethyl-1,3-dioxan-4-yl]acetate 
• 88675-31-4 2-bromo-1-(4-fluorophenyl)-2-phenylethan-1-one 

Downstream Products

• 1351764-67-4 (3R,5R)-7-[2-(4-fluorophenyl)-5-isopropyl-3-phenyl-4-[(4-hydroxymethyl-phenylamino)carbonyl]-pyrrol-1-yl]-3,5-dihydroxy-heptanoic acid sodium salt 
• 936756-74-0 tert-butyl 2-[(4R,6R)-6-{2-[2-(4-fluorophenyl)-4-{[4-(hydroxymethyl)phenyl]carbamoyl}-3-phenyl-5-(propan-2-yl)-1H-pyrrol-1-yl]ethyl}-2,2-dimethyl-1,3-dioxan-4-yl]acetate 

Relevant articles and documents

METHOD OF PREPARING(3R,5R)-7-(2-(4-FLUOROPHENYL)-5-ISOPROPYL-3-PHENYL-4-((4-HYDROXYMETHYLPHENYLAMINO)CARBONYL)-PYRROL-1-YL)-3,5-DIHYDROXY-HEPTANOIC ACID HEMI CALCIUM SALT, AND METHOD OF PREPARING INTERMEDIATES USED THEREIN

The present invention provides a method for preparing (3R,5R)-7-(2-(4-flurophenyl)-5-isopropyl-3-phenyl-4-((4-hydroxymethylphenylamino)carbonyl)-pyrrole-1-yl)-3,5-dihydroxy heptanoic acid hemicalcium salt. The preparation method of the present invention is performed in a convergent synthesis manner in which main structural moieties of a (3R,5R)-7-(2-(4-flurophenyl)-5-isopropyl-3-phenyl-4-((4-hydroxymethylphenylamino)carbonyl)-pyrrole-1-yl)-3,5-dihydroxy heptanoic acid hemicalcium salt are independently synthesized, and then coupled. Accordingly, related substances can be easily controlled and preparing time can be reduced, thus improving the productivity of a compound, and the yield of a final compound can also be increased.

PROCESS FOR (3R, 5R)-7-[2-(4-FLUOROPHENYL)-5-ISOPROPYL-3-PHENYL-4- [(4-HYDROXY METHYL PHENYL AMINO) CARBONYL]-PYRROL-1-YL]-3, 5-DIHYDROXY-HEPTANOIC ACID HEMI CALCIUM SALT

The present invention relates to processes for the manufacture of (3 R, 5R)-7-[2-(4- fluorophenyl)-5-isopropyl-3-phenyl-4- [(4-hydroxy methyl phenyl amino) carbonyl]- pyrrol-l-yl]-3,5-dihydroxy-heptanoic acid hemi calcium salt.