80569-59-1

Basic information

• Product Name: 4-methyl-5-phenyl-2H-1,2,3-triazole
• Synonyms: 4-methyl-5-phenyl-2H-1,2,3-triazole
• CAS NO: 80569-59-1
• Molecular Weight: 159.191
• Mol File: 80569-59-1.mol
• Article Data: 8

Chemical Properties

• CAS DataBase Reference: 4-methyl-5-phenyl-2H-1,2,3-triazole(CAS DataBase Reference)
• NIST Chemistry Reference: 4-methyl-5-phenyl-2H-1,2,3-triazole(80569-59-1)
• EPA Substance Registry System: 4-methyl-5-phenyl-2H-1,2,3-triazole(80569-59-1)

Safety Data

• Hazardous Substances Data: 80569-59-1(Hazardous Substances Data)

Upstream product

• 705-60-2 (2-nitroprop-1-enyl)benzene 
• 673-32-5 1-Phenylprop-1-yne 
• 79-24-3 Nitroethane 
• 100-52-7 benzaldehyde 

Relevant articles and documents

Aluminium(III) Chloride-Catalyzed Three-Component Condensation of Aromatic Aldehydes, Nitroalkanes and Sodium Azide for the Synthesis of 4-Aryl-NH-1,2,3-triazoles

An aluminium(III) chloride-catalyzed three-component reaction of aromatic aldehydes, nitroalkanes, and sodium azide has been developed; this reaction sequence can be applied to a broad substrate scope and affords the corresponding 4-aryl-NH-1,2,3-triazoles in good to excellent yields. The milder reaction conditions and easier operation make this AlCl3-catalyzed protocol more advantageous for the synthesis of 4-aryl-NH-1,2,3-triazoles. (Figure presented.).

Synthesis and Fungicidal Activities of 2-Substituted-4-methyl-5-aryl-2H-1,2,3-triazole Derivatives

A series of 2-substituted-4-methyl-5-aryl-2H-1,2,3-triazoles was synthesized using aromatic aldehyde, nitroethane, and sodium azide as the starting materials in the yield of 56-96%. The structures of title compounds were characterized by nuclear magnetic resonance, mass spectrometry, and elemental analyses. All of the target compounds were evaluated in vitro for their fungicidal activity against Gibberella zeae, Phytophthora capsici, Alternaria alternate, Botrytis cinerea, Rhizoctonia solani, and Sclerotinia sclerotiorum at a concentration of 25 mg/L. The bio-assay results revealed that most of the compounds had preliminary fungicidal activity against G. zeae, P. capsici, and A. alternate. Among them, the inhibitory rate of compound 3b to Phytophthora capsici was up to 82.0%.

A NH - 1, 2, 3 - triazole synthetic method

The invention discloses a method for synthesizing NH-1,2,3-triazole shown by a formula (I). Under the catalytic action of a Lewis acid catalyst, nitroalkene shown by a formula (II) and hydrazoic acid salt undergo 1,3-dipolar cycloaddition, wherein Ar is p