80576-76-7

Basic information

• Product Name: Benzoic acid, 4-[2-(2,4-diamino-6-pteridinyl)-1-methylethyl]-
• CAS NO: 80576-76-7
• Molecular Formula: C16H16N6O2
• Molecular Weight: 324.342
• Mol File: 80576-76-7.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: Benzoic acid, 4-[2-(2,4-diamino-6-pteridinyl)-1-methylethyl]-(CAS DataBase Reference)
• NIST Chemistry Reference: Benzoic acid, 4-[2-(2,4-diamino-6-pteridinyl)-1-methylethyl]-(80576-76-7)
• EPA Substance Registry System: Benzoic acid, 4-[2-(2,4-diamino-6-pteridinyl)-1-methylethyl]-(80576-76-7)

Safety Data

• Hazardous Substances Data: 80576-76-7(Hazardous Substances Data)

Upstream product

• 619-64-7 p-ethylbenzoic acid 
• 272779-21-2 4-[2-(2,4-diamino-pteridin-6-yl)-1-methoxycarbonyl-1-methyl-ethyl]-benzoic acid methyl ester 
• 77959-48-9 4-(1-methoxycarbonyl-ethyl)-benzoic acid methyl ester 
• 52787-14-1 methyl 4-(2-methoxy-2-oxoethyl)benzoate 
• 272779-22-3 4-[1-carboxy-2-(2,4-diamino-pteridin-6-yl)-1-methyl-ethyl]-benzoic acid 
• 1004-74-6 2,4,5,6-tetraaminopyrimidine 
• 80576-74-5 4-(3-Bromo-1-methyl-4-oxo-butyl)-benzoic acid 

Downstream Products

• 80587-59-3 d,L-10-methyl-10-deazaminopterin 
• 80576-77-8 10-methyl-10-deazaaminopterin 

Relevant articles and documents

Analogues of the potent nonpolyglutamatable antifolate N(α)-(4-amino-4- deoxypteroyl)-N(δ)-hemiphthaloyl-L-ornithine (PT523) with modifications in the side chain, p-aminobenzoyl moiety, or 9,10-bridge: Synthesis and in vitro antitumor activity

Seven N(α)-(4-amino-4-deoxypteroyl)-N(δ)-hemiphthaloyl-L-ornithine (2, PT523) analogues were synthesized by modifications of the literature synthesis of the corresponding AMT (1) analogues and were tested as inhibitors of tumor cell growth. In growth assa