80683-81-4Relevant articles and documents
A Mild Heteroatom (O -, N -, and S -) Methylation Protocol Using Trimethyl Phosphate (TMP)-Ca(OH) 2Combination
Tang, Yu,Yu, Biao
, (2022/03/27)
A mild heteroatom methylation protocol using trimethyl phosphate (TMP)-Ca(OH)2combination has been developed, which proceeds in DMF, or water, or under neat conditions, at 80 °C or at room temperature. A series of O-, N-, and S-nucleophiles, including phenols, sulfonamides, N-heterocycles, such as 9H-carbazole, indole derivatives, and 1,8-naphthalimide, and aryl/alkyl thiols, are suitable substrates for this protocol. The high efficiency, operational simplicity, scalability, cost-efficiency, and environmentally friendly nature of this protocol make it an attractive alternative to the conventional base-promoted heteroatom methylation procedures.
SYNTHESIS OF RACEMIC ALKALOID DIPTHALINE AND ITS STRUCTURAL ANALOGS AND THEIR ANTIHYPOXIC ACTIVITY
Biktimirova, L. A.,Likhovskikh, V. V.,Tolstikova, O. V.,Tolstikova, T. G.,Tolstikov, A. G.
, p. 843 - 846 (2007/10/02)
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