80684-66-8

Basic information

• Product Name: 1,2-(F-benz)isoxazol-3(2H)-one
• Synonyms: 1,2-(F-benz)isoxazol-3(2H)-one
• CAS NO: 80684-66-8
• Molecular Weight: 207.084
• Mol File: 80684-66-8.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 1,2-(F-benz)isoxazol-3(2H)-one(CAS DataBase Reference)
• NIST Chemistry Reference: 1,2-(F-benz)isoxazol-3(2H)-one(80684-66-8)
• EPA Substance Registry System: 1,2-(F-benz)isoxazol-3(2H)-one(80684-66-8)

Safety Data

• Hazardous Substances Data: 80684-66-8(Hazardous Substances Data)

Upstream product

• 80684-62-4 F-benzohydroxamic acid 

Relevant articles and documents

ortho-Disubstituted F-Benzenes. III. Preparation of (F-Benzo)heterocyclic Compounds from F-Benzoic Acid and F-Phenol, and the Reactions of Some Intermediary F-Benzoyl- and F-Phenoxy Compounds

With the intention of achieving the selective ortho-substitution of F-benzoic acid and F-phenol via intramolecular nucleophilic cyclization, preparation of some requisite precursory F-benzoyl- and F-phenoxy compounds and their nucleophilic cyclization reactions were examined. 1,2-(F-Benz)isoxazol-3(2H)-one, 2-(p-tolyl)-1,2-(F-benz)isoxazol-3(2H)-one, 1,3-dimethyl(F-benzo)pyrimidine-2,4(1H,3H)-dione, and 1,4-(F-benz)oxazin-3(2H)-one were obtained from the respective precursory F-benzohydroxamic acid, N-(p-tolyl)-N-hydroxy-F-benzamide, N,N'-dimethyl-N-(F-benzoyl)urea, and 2-(F-phenoxy)acetohydrazide.Attempted cyclizations of 2-(F-phenoxy)acetohydroxamic acid and (F-phenoxy)acetic acid were accompanied by simultaneous ring-opening and resulted in the formation of the identical product : (2-hydroxy-F-phenoxy)acetic acid.Transamidation of ethyl F-benzoate with hydroxylamine failed to give F-benzohydroxamic acid, which was then obtained by the catalytic debenzylation of N-benzyloxy-F-benzamide.