80691-81-2

Basic information

• Product Name: 2,5-Diaminothiophene-3,4-dicarboxylic acid diethyl ester
• Synonyms: 2,5-Diaminothiophene-3,4-dicarboxylic acid diethyl ester;3,4-diethyl 2,5-diaMinothiophene-3,4-dicarboxylate;Diethyl 2,5-diaMinothiophene-3,4-dicarboxylate;2,5-Diamino-3,4-thiophenedicarboxylic acid diethyl ester
• CAS NO: 80691-81-2
• Molecular Formula: C₁₀H₁₄N₂O₄S
• Molecular Weight: 258.29
• Mol File: 80691-81-2.mol
• Article Data: 9

Chemical Properties

• Melting Point: 155-156 °C(Solv: ethyl acetate (141-78-6); hexane (110-54-3))
• Boiling Point: 403.3°C at 760 mmHg
• Flash Point: 197.7°C
• Appearance: /
• Density: 1.343
• Vapor Pressure: 1.03E-06mmHg at 25°C
• Refractive Index: 1.601
• Storage Temp.: 2-8°C(protect from light)
• PKA: 0.56±0.10(Predicted)
• CAS DataBase Reference: 2,5-Diaminothiophene-3,4-dicarboxylic acid diethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 2,5-Diaminothiophene-3,4-dicarboxylic acid diethyl ester(80691-81-2)
• EPA Substance Registry System: 2,5-Diaminothiophene-3,4-dicarboxylic acid diethyl ester(80691-81-2)

Safety Data

• Hazardous Substances Data: 80691-81-2(Hazardous Substances Data)

Usage

General Description

2,5-Diaminothiophene-3,4-dicarboxylic acid diethyl ester is a chemical compound usually used in the field of organic chemistry. It is utilized as an intermediate in the synthesis of various compounds due to its distinct structural properties: two amino groups (-NH2) on the thiophene ring, and two ester-containing carboxylic acids. These groups allow it to participate in a variety of chemical reactions. 2,5-Diaminothiophene-3,4-dicarboxylic acid diethyl ester is often subjected to further transformations to result in new molecules with potential applications in pharmaceuticals, polymers and dyes production.

InChI:InChI=1/C10H14N2O4S/c1-3-15-9(13)5-6(10(14)16-4-2)8(12)17-7(5)11/h3-4,11-12H2,1-2H3

Upstream product

• 104680-25-3 diethyl 2-aminothiophene-3,4-dicarboxylate 
• 105-56-6 ethyl 2-cyanoacetate 

Downstream Products

• 80691-85-6 3,6-Diphenylthieno<2,3-d:5,4-d'>dipyrimidin-2,4,5,7(1H,8H)-tetraon 
• 147235-54-9 diethyl 2,5-bis[(triphenyl-λ⁵-phosphanylidene)amino]thiophene-3,4-dicarboxylate 
• 910464-94-7 2,5-bis-phenyliminomethyleneamino-thiophene-3,4-dicarboxylic acid diethyl ester 
• 1026366-09-5 2,5-bis-p-tolyliminomethyleneamino-thiophene-3,4-dicarboxylic acid diethyl ester 
• 1027654-41-6 2,5-bis-m-tolyliminomethyleneamino-thiophene-3,4-dicarboxylic acid diethyl ester 
• 1027591-44-1 2,5-bis-(4-chloro-phenyliminomethyleneamino)-thiophene-3,4-dicarboxylic acid diethyl ester 
• 1026081-99-1 2-morpholin-4-yl-4-oxo-3-phenyl-6-phenyliminomethyleneamino-3,4-dihydro-thieno[2,3-d]pyrimidine-5-carboxylic acid ethyl ester 
• 1026256-05-2 4-oxo-3-phenyl-6-phenyliminomethyleneamino-2-piperidin-1-yl-3,4-dihydro-thieno[2,3-d]pyrimidine-5-carboxylic acid ethyl ester 
• 1026525-62-1 2-morpholin-4-yl-4-oxo-3-phenyl-6-p-tolyliminomethyleneamino-3,4-dihydro-thieno[2,3-d]pyrimidine-5-carboxylic acid ethyl ester 
• 1026748-40-2 4-oxo-3-phenyl-2-piperidin-1-yl-6-p-tolyliminomethyleneamino-3,4-dihydro-thieno[2,3-d]pyrimidine-5-carboxylic acid ethyl ester 
• 1026504-38-0 6-(4-chloro-phenyliminomethyleneamino)-2-morpholin-4-yl-4-oxo-3-phenyl-3,4-dihydro-thieno[2,3-d]pyrimidine-5-carboxylic acid ethyl ester 
• 1027220-71-8 C₃₅H₃₀N₃O₄PS 
• 1026872-89-8 6-(4-chloro-phenyliminomethyleneamino)-4-oxo-3-phenyl-2-piperidin-1-yl-3,4-dihydro-thieno[2,3-d]pyrimidine-5-carboxylic acid ethyl ester 

Relevant articles and documents

Optimized synthesis and simple purification of 2,5-diamino-thiophene-3,4- dicarboxylic acid diethyl ester

A stable diamino thiophene was synthesized in high purity with a three-fold increase in yield over previous reports via simple crystallization using inexpensive reagents. Copyright Taylor & Francis Group, LLC.

Discovery of diethyl 2,5-diaminothiophene-3,4-dicarboxylate derivatives as potent anticancer and antimicrobial agents and screening of anti-diabetic activity: Synthesis and in vitro biological evaluation. Part 1

Series of diethyl 2,5-diaminothiophene-3,4-dicarboxylate (DDTD) derivatives: azomethines of DDTD (2a el) have been synthesized and screened for their anticancer, antimicrobial and anti-diabetic activities. The novel synthesized compounds were characterize

A 2,5-diamino -3,4-thiophene dicarboxylate ethyl derivatives preparation method and use

The invention relates to a preparation method and application of ethyl 2,5-diamido-3,4-thienyldicarboxylate derivatives. Sulfur and ethyl cyanoacetate used as raw materials are condensed with substitution benzaldehyde or arylheterocyclo aldehyde under the