807618-13-9Relevant articles and documents
Structure-Guided Discovery of Aminoquinazolines as Brain-Penetrant and Selective LRRK2 Inhibitors
Acton, John J.,Adpressa, Donovon,Ardolino, Michael J.,Bennett, David Jonathan,Chau, Ryan W.,Ciaccio, Paul J.,Dimauro, Erin F.,Faltus, Robert,Fell, Matthew J.,Fuller, Peter H.,Gulati, Anmol,Hegde, Laxminarayan G.,Johnson, Rebecca E.,Kattar, Solomon D.,Kennedy, Matthew E.,Keylor, Mitchell H.,Lesburg, Charles A.,Lin, Shishi,Liu, Ping,Margrey, Kaila A.,McMinn, Spencer E.,Morriello, Gregori J.,Neelamkavil, Santhosh,Nogle, Lisa,Otte, Karin M.,Palte, Rachel L.,Piesvaux, Jennifer,Pio, Barbara,Poremba, Kelsey E.,Simov, Vladimir,Su, Jing,Wood, Harold B.,Woodhouse, Janice D.,Xiong, Tina,Yan, Xin,Zarate, Cayetana
supporting information, p. 838 - 856 (2022/01/20)
The leucine-rich repeat kinase 2 (LRRK2) protein has been genetically and functionally linked to Parkinson's disease (PD), a disabling and progressive neurodegenerative disorder whose current therapies are limited in scope and efficacy. In this report, we
HETEROCYCLIC GLP-1 AGONISTS
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Page/Page column 141, (2021/11/06)
This disclosure relates to GLP-1 agonists of Formula (I): including pharmaceutically acceptable salts and solvates thereof, and pharmaceutical compositions including the same.
HETEROARYL COMPOUNDS FOR TREATING HUNTINGTON'S DISEASE
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Page/Page column 214, (2020/01/24)
The present description relates to compounds, forms, and pharmaceutical compositions thereof and methods of using such compounds, forms, or compositions thereof for treating or ameliorating Huntington's disease. In particular, the present description relates to substituted benzothiazole compounds of Formula (I) or (II), forms and pharmaceutical compositions thereof and methods of using such compounds, forms, or compositions thereof for treating or ameliorating Huntington's disease.