807620-96-8

Basic information

• Product Name: Pyridine, 2-[2-(3-bromo-5-fluorophenyl)-2H-tetrazol-5-yl]-
• CAS NO: 807620-96-8
• Molecular Formula: C12H7BrFN5
• Molecular Weight: 320.123
• Mol File: 807620-96-8.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: Pyridine, 2-[2-(3-bromo-5-fluorophenyl)-2H-tetrazol-5-yl]-(CAS DataBase Reference)
• NIST Chemistry Reference: Pyridine, 2-[2-(3-bromo-5-fluorophenyl)-2H-tetrazol-5-yl]-(807620-96-8)
• EPA Substance Registry System: Pyridine, 2-[2-(3-bromo-5-fluorophenyl)-2H-tetrazol-5-yl]-(807620-96-8)

Safety Data

• Hazardous Substances Data: 807620-96-8(Hazardous Substances Data)

Upstream product

• 807620-95-7 N-(3-bromo-5-fluorophenyl)acetamide 
• 134168-97-1 3-bromo-5-fluoroaniline 
• 1435-51-4 1,3-dibromo-5-fluorobenzene 
• 1121-60-4 pyridine-2-carbaldehyde 

Relevant articles and documents

3-[3-Fluoro-5-(5-pyridin-2-yl-2H-tetrazol-2-yl)phenyl]-4-methylpyridine: A highly potent and orally bioavailable metabotropic glutamate subtype 5 (mGlu5) receptor antagonist

Structure-activity relationship studies performed around 3-fluoro-5-(5-pyridin-2-yl-2H-tetrazol-2-yl)benzonitrile for the purposes of developing novel mGlu5 receptor antagonists are described. Synthesis of a series of four-ring tetrazoles led to the discovery of 3-[3-fluoro-5-(5-pyridin-2-yl- 2H-tetrazol-2-yl)phenyl]-4-methylpyridine (26), a highly potent, brain penetrant, tetrazole-based mGlu5 receptor antagonist. Structure-activity relationship studies performed around 3-fluoro-5-(5-pyridin-2-yl-2H-tetrazol-2- yl)benzonitrile for the purpose of developing novel mGlu5 receptor antagonists are described. Synthesis of a series of four-ring tetrazoles led to the discovery of 3-[3-fluoro-5-(5-pyridin-2-yl-2H-tetrazol-2-yl)phenyl]-4- methylpyridine, a highly potent, brain penetrant, azole-based mGlu5 receptor antagonist.