80772-85-6Relevant articles and documents
Acylation of 2-benzylpyridine N-oxides and subsequent in situ [3,3]-sigamatropic rearrangement reaction
Antilla, Jon C.,Jing, Hua-qing,Li, Hong-liang
, (2020/09/22)
An effective method for the acylation of 2-benzylpyridine N-oxides and their fast in situ [3,3]-sigmatropic rearrangement was reported. This transformation has a wide substrate scope under mild conditions, giving moderate to excellent yields. The application for the synthesis of chiral phenyl-2-pyridylmethanol products was briefly explored. Furthermore, an interesting example of tandem substitution and in situ [3,3]-sigamatropic rearrangement of 2-benzylpyridine N-oxide with benzenecarboximidoyl chloride was reported.
Palladium-catalyzed benzylic cross-couplings of pyridine N-oxides
Mai, Wenpeng,Yuan, Jinwei,Li, Zhicheng,Yang, Liangru,Xiao, Yongmei,Mao, Pu,Qu, Lingbo
supporting information; experimental part, p. 938 - 942 (2012/06/01)
Palladium-catalyzed C-H couplings (CSP3-C SP2) of pyridine N-oxides with benzyl chloride derivatives is reported. It provides a novel and easy process for the synthesis of 2-benzylpyridine derivatives through benzylic cross-couplings of pyridine N-oxides. Georg Thieme Verlag Stuttgart · New York.
Catalyst and base controlled site-selective sp2 and sp3 direct arylation of azine N-oxides
Schipper, Derek J.,Campeau, Louis-Charles,Fagnou, Keith
experimental part, p. 3155 - 3164 (2009/08/15)
Site-selective direct arylation of both sp2 and sp3 sites on azine N-oxide substrates is described. The arylation reactions are carried out in either a divergent manner or a sequential manner. The sp3 arylation reaction is applied to the synthesis of the natural products, papaverine and crykonisine, and a rationale for low reactivity of electron-deficient aryl halides is provided. Mechanistic investigations point toward the intimate involvement of the base in the mechanism of these reactions.