80775-43-5

Basic information

• Product Name: 1-Butanone, 1-(5-bromo-2-thienyl)-4-chloro-
• Synonyms: 1-(5-bromothiophen-2-yl)-4-chlorobutan-1-one;4-chloro-1-(5-bromo-2-thienyl)butan-1-one
• CAS NO: 80775-43-5
• Molecular Formula: C8H8BrClOS
• Molecular Weight: 267.574
• Mol File: 80775-43-5.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 1-Butanone, 1-(5-bromo-2-thienyl)-4-chloro-(CAS DataBase Reference)
• NIST Chemistry Reference: 1-Butanone, 1-(5-bromo-2-thienyl)-4-chloro-(80775-43-5)
• EPA Substance Registry System: 1-Butanone, 1-(5-bromo-2-thienyl)-4-chloro-(80775-43-5)

Safety Data

• Hazardous Substances Data: 80775-43-5(Hazardous Substances Data)

Usage

Appearance

White to light yellow solid

Usage

a. Intermediate in the production of pharmaceuticals
b. Intermediate in the production of agrochemicals
c. Intermediate in the production of other specialty chemicals

Application in research and development

Building block for the synthesis of various molecules

Potential applications

Medicinal chemistry and drug discovery

Safety considerations

a. Handle with care
b. Follow safety regulations
c. May pose hazards to human health and the environment if not properly managed

Upstream product

• 1003-09-4 2-bromothiophene 
• 4635-59-0 4-Chlorobutanoyl chloride 
• 3141-27-3 2,5-dibromothiophen 

Relevant articles and documents

Thienylhalomethylketones: Irreversible glycogen synthase kinase 3 inhibitors as useful pharmacological tools

Thienylhalomethylketones, whose chemical, biological, and pharmaceutical data are here reported, are the first irreversible inhibitors of GSK-3β described to date. Their inhibitory activity is likely related to the cysteine residue present in the ATP-binding site, which is proposed as a relevant residue for modulation of GSK-3 activity. The good cell permeability of the compounds allows them to be used in different cell models. Overall, the results presented here support the potential use of halomethylketones as pharmacological tools for the study of GSK-3β functions and suggest a new mechanism for GSK-3β inhibition that may be considered for further drug design.

Bromothiophene Reactions. I. Friedel-Crafts Acylation

Friedel-Crafts acylation of 2,5-dibromo- and 2,3,5-tribromothiophenes with different acyl chlorides and anhydrous aluminium trichloride has been studied.The reaction afforded a mixture of acyl derivatives and tetrabromothiophene.The results obtained suggest a mechanism which involves the formation of bromine cations in the reaction medium.Several products obtained in this reaction are described.