80812-44-8 Usage
Nitroimidazole derivative
A compound derived from the modification of the basic nitroimidazole structure, which is known for its various biological activities.
Pharmaceutical applications
The potential use of this compound in the development of medications for treating various diseases and conditions.
Antimicrobial properties
The ability of the compound to inhibit or kill microorganisms, such as bacteria and viruses.
Antifungal properties
The capacity of the compound to prevent the growth or destroy fungi, which can cause infections in humans and other organisms.
Radiosensitizer in cancer treatment
The potential of the compound to enhance the effectiveness of radiation therapy in destroying cancer cells.
Inhibition of parasite growth
The compound's ability to suppress the growth and reproduction of certain parasites, which can cause diseases such as giardiasis and trichomoniasis.
Potential therapy for giardiasis and trichomoniasis
The consideration of the compound as a possible treatment option for these parasitic infections, which can cause gastrointestinal and genital symptoms, respectively.
Biological activities
The various effects and interactions that the compound has with biological systems, indicating its potential for future applications in medicine and healthcare.
Check Digit Verification of cas no
The CAS Registry Mumber 80812-44-8 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 8,0,8,1 and 2 respectively; the second part has 2 digits, 4 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 80812-44:
(7*8)+(6*0)+(5*8)+(4*1)+(3*2)+(2*4)+(1*4)=118
118 % 10 = 8
So 80812-44-8 is a valid CAS Registry Number.
80812-44-8Relevant articles and documents
Synthesis and In-vitro antibacterial activity of 5-substituted 1-methyl-4-nitro-1H-imidazoles
Letafat, Bahram,Emami, Saeed,Aliabadi, Alireza,Mohammadhosseini, Negar,Moshafi, Mohammad Hassan,Asadipour, Ali,Shafiee, Abbas,Foroumadi, Alireza
experimental part, p. 497 - 501 (2009/04/04)
A series of 5-substituted 1-methyl-4-nitro-1H-imidazole derivatives were synthesized and evaluated for in-vitro antibacterial activity against a panel of microorganisms including Staphylococcus aureus, Staphylococcus epidermidis, Bacillus subtilis, Esherichia coli, Klebsiella pneumonia, Entrobacter aerogenes, and Helicobacter pylori using conventional agar dilution method. Among the test compounds, 1-methyl-4-nitro-5-(phenylsulfonyl)-1H-imidazole was the most potent against Gram-positive bacteria, with a MIC value of ≤8 μg/mL. All compounds showed no significant activity against Gram-negative bacteria at concentrations ≤64 μg/mL The MIC values against 15 clinical isolates of H. pylori indicated that compounds 10 and 11 were the most active compounds in this series in terms of inhibiting the growth of H. pylori (MIC = 2 μg/mL). It was also demonstrated that their corresponding activities were four times larger than that of metronidazole.
