80824-77-7

Basic information

• Product Name: Benzamide, N-[4-(benzoyloxy)phenyl]-
• CAS NO: 80824-77-7
• Molecular Formula: C20H15NO3
• Molecular Weight: 317.344
• Mol File: 80824-77-7.mol
• Article Data: 10

Chemical Properties

• CAS DataBase Reference: Benzamide, N-[4-(benzoyloxy)phenyl]-(CAS DataBase Reference)
• NIST Chemistry Reference: Benzamide, N-[4-(benzoyloxy)phenyl]-(80824-77-7)
• EPA Substance Registry System: Benzamide, N-[4-(benzoyloxy)phenyl]-(80824-77-7)

Safety Data

• Hazardous Substances Data: 80824-77-7(Hazardous Substances Data)

Upstream product

• 623-11-0 1-methyl-4-nitrosobenzene 
• 100063-31-8 5-hydroxymethyl-furan-2-carbaldehyde-(4-hydroxy-phenylimine) 
• 98-88-4 benzoyl chloride 
• 26850-26-0 2-((4-hydroxyphenyl)amino)-2-methylpropanenitrile 
• 123-30-8 4-amino-phenol 
• 81235-20-3 3-(benzothiazol-2-ylthio)-1,2-benzisothiazole 1,1-dioxide 
• 149-30-4 2-Mercaptobenzothiazole 
• 65-85-0 benzoic acid 
• 567-19-1 3-chloro-1,2-benzisothiazole 1,1-dioxide 
• 857999-95-2 2-(4-hydroxy-anilino)-2-phenyl-propionitrile 
• 75-98-9 Trimethylacetic acid 
• 17688-44-7 S-(benzoxazol-2-yl) thiobenzolate 
• 54769-36-7 N-benzoyloxybenzotriazole 
• 33388-23-7 3-benzoyl-2(3H)-benzoxazolethione 

Downstream Products

• 15457-50-8 p-benzoylaminophenol 
• 7403-13-6 acetic acid-(4-hydroxy-2.6-dinitro-anilide) 
• 32654-60-7 4-amino-3,5-dinitrophenol 
• 610-81-1 4-hydroxy-2-nitroaniline 
• 586-11-8 3,5-dinitrophenol 
• 720-98-9 4-benzoyloxy-aniline 

Relevant articles and documents

Synthesis and pharmacological evaluation of piperidine (piperazine)-amide substituted derivatives as multi-target antipsychotics

We report the optimisation of a series of novel amide-piperidine (piperazine) derivatives using the multiple ligand approach with dopamine and serotonin receptors. Of the derivatives, compound 11 exhibited high affinity for the D2, 5-HT1A, and 5-HT2A receptors, but low affinity for the 5-HT2C and histamine H1 receptors and human ether-a-go-go-related gene (hERG) channels. In vivo, compound 11 reduced apomorphine-induced climbing, MK-801-induced hyperactivity and DOI-induced head twitching without observable catalepsy, even at the highest dose tested. In addition, it exhibited suppression in a CAR test. Furthermore, in a novel object recognition task, it displayed procognition properties. Therefore, compound 11 is a promising candidate multi-target antipsychotic.

1,2-Benzisoxazol-3-yl Diphenyl Phosphate: A New, Reactive Activating Agent for the Synthesis of Amides, Esters, and Peptides via Condensation

A new activating agent for condensations, 1,2-benzisoxazol-3-yl diphenyl phosphate (1), was readily prepared in high yield by the reaction of 1,2-benzisoxazol-3-ol (2) with diphenyl phosphorochloridate (3) in the presence of triethylamine in benzene.The reaction of the carboxylic acids with the amines in the presence of 1 was investigated by two procedures, a two-step method and a one-step procedure.Both methods gave the corresponding amides and esters in high yields under mild conditions, but the one-step procedure was found to be superior to the two-step procedure because of its simplicity and speed.Furthermore, the activating agent 1 was shown to be a useful peptide forming reagent.

2(3H)-BENZOXAZOLETHIONE.

A new condensing agent, N,N prime -carbonyldi left bracket 2(3H)-benzoxazolethione right bracket , was readily prepared by the reaction of 2-benzoxazolethiol and trichloromethyl chloroformate in benzene. The condensing agent is shown to be useful for the preparation of amides, esters, and dipeptides under mild conditions. A successful polyamide synthesis by the polycondensation of isophthalic acid with diamines using the condensing agent is also described.