80873-62-7 Usage
Description
(S)-Nitrendipine, also known as (-)-Nitrendipine, is a dihydropyridine calcium channel blocker with a chiral center, resulting in two enantiomers: (R)and (S)-Nitrendipine. The (S)-enantiomer is the biologically active form, which selectively blocks L-type calcium channels in vascular smooth muscle cells, leading to vasodilation and a reduction in blood pressure.
Used in Pharmaceutical Industry:
(S)-Nitrendipine is used as an antihypertensive drug for the treatment of hypertension. It functions by selectively blocking L-type calcium channels in vascular smooth muscle cells, resulting in vasodilation and a decrease in peripheral vascular resistance, which in turn lowers blood pressure. This selective action makes (S)-Nitrendipine a more effective and safer option compared to the racemic mixture of (R)and (S)-enantiomers, as the (R)-enantiomer is less active and may contribute to side effects.
Check Digit Verification of cas no
The CAS Registry Mumber 80873-62-7 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 8,0,8,7 and 3 respectively; the second part has 2 digits, 6 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 80873-62:
(7*8)+(6*0)+(5*8)+(4*7)+(3*3)+(2*6)+(1*2)=147
147 % 10 = 7
So 80873-62-7 is a valid CAS Registry Number.
InChI:InChI=1/C18H20N2O6/c1-5-26-18(22)15-11(3)19-10(2)14(17(21)25-4)16(15)12-7-6-8-13(9-12)20(23)24/h6-9,16,19H,5H2,1-4H3/t16-/m0/s1
80873-62-7Relevant articles and documents
Synthesis and characterization of impurities of barnidipine hydrochloride, an antihypertensive drug substance
Cheng, Zhi-Gang,Dai, Xu-Yong,Li, Li-Wei,Wan, Qiong,Ma, Xiang,Xiang, Guang-Ya
, p. 1344 - 1352 (2014/02/14)
Barnidipine hydrochloride is a long term dihydropyridine calcium channel blocker used for the treatment of hypertension. During the process development of barnidipine hydrochloride, four barnidipine impurities were detected by high-performance liquid chromatography (HPLC) with an ordinary column (Agilent ZORBAX Eclipse XDB-C18, 150 mm × 4.6 mm, 5 m). All these impurities were identified, synthesized, and subsequently characterized by their respective spectral data (MS, 1H-NMR, and 13C-NMR). The identification of these impurities should be useful for quality control in the manufacture of barnidipine.