80971-34-2

Basic information

• Product Name: 3'-O-t-butyldimethylsilyl-5'-O-dimethoxytrityl-1-[5-methyl-4-triazolylpyrimidin-2(1H)-onyl]-β-D-2'-deoxyriboside
• Synonyms: 3'-O-t-butyldimethylsilyl-5'-O-dimethoxytrityl-1-[5-methyl-4-triazolylpyrimidin-2(1H)-onyl]-β-D-2'-deoxyriboside
• CAS NO: 80971-34-2
• Molecular Weight: 709.918
• Mol File: 80971-34-2.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 3'-O-t-butyldimethylsilyl-5'-O-dimethoxytrityl-1-[5-methyl-4-triazolylpyrimidin-2(1H)-onyl]-β-D-2'-deoxyriboside(CAS DataBase Reference)
• NIST Chemistry Reference: 3'-O-t-butyldimethylsilyl-5'-O-dimethoxytrityl-1-[5-methyl-4-triazolylpyrimidin-2(1H)-onyl]-β-D-2'-deoxyriboside(80971-34-2)
• EPA Substance Registry System: 3'-O-t-butyldimethylsilyl-5'-O-dimethoxytrityl-1-[5-methyl-4-triazolylpyrimidin-2(1H)-onyl]-β-D-2'-deoxyriboside(80971-34-2)

Safety Data

• Hazardous Substances Data: 80971-34-2(Hazardous Substances Data)

Upstream product

• 18162-48-6 tert-butyldimethylsilyl chloride 
• 50-89-5 thymidine 
• 40615-39-2 5'-O-(4-4'-dimethoxytrityl)thymidine 
• 40615-36-9 4,4'-dimethoxytrityl chloride 
• 288-88-0 1,2,4-Triazole 
• 80971-33-1 5'-O-(4,4'-dimethoxytrityl)-3'-O-(t-butyldimethylsilyl)-2'-deoxythymidine 

Downstream Products

• 1569273-40-0 C₅₂H₆₇N₇O₁₄P₂ 
• 1569273-39-7 C₄₃H₅₀N₅O₁₃P 
• 1569273-38-6 C₄₉H₆₄N₅O₁₃PSi 
• 80971-36-4 C₃₈H₄₉N₃O₆Si 
• 1396763-92-0 3'-O-(tert-butyldimethylsilyl)-5'-O-(4,4'-dimethoxytrityl)-O₄-(phenoxyacetyloxybutyl)thymidine 
• 1396763-95-3 5'-O-(4,4'-dimethoxytrityl)-O₄-(phenoxyacetyloxyheptyl)thymidine 
• 1396763-94-2 5'-O-(4,4'-dimethoxytrityl)-O₄-(phenoxyacetyloxybutyl)thymidine 
• 1396763-93-1 3'-O-(tert-butyldimethylsilyl)-5'-O-(4,4'-dimethoxytrityl)-O₄-(phenoxyacetyloxyheptyl)thymidine 
• 1396763-84-0 3'-O-(tert-butyldimethylsilyl)-5'-O-(4,4'-dimethoxytrityl)-O₄-(hydroxybutyl)thymidine 
• 1396763-87-3 1-{O₄-[3'-O-(tert-butyldimethylsilyl)-5'-O-(4,4'-dimethoxytrityl)thymidyl]}-7-{O₄-[3'-O-(tert-butyldimethylsilyl)-5'-O-(4,4'-dimethoxytrityl)thymidyl]}heptane 
• 1396763-86-2 1-{O₄-[3'-O-(tert-butyldimethylsilyl)-5'-O-(4,4'-dimethoxytrityl)thymidyl]}-4-{O₄-[3'-O-(tert-butyldimethylsilyl)-5'-O-(4,4'-dimethoxytrityl)thymidyl]}butane 
• 1396763-85-1 3'-O-(tert-butyldimethylsilyl)-5'-O-(4,4'-dimethoxytrityl)-O₄-(hydroxyheptyl)thymidine 
• 80971-35-3 3'-O-(tert-butyldimethylsilyl)-5'-O-(4,4'-dimethoxytrityl)-2'-deoxy-5-methylcytidine 

Relevant articles and documents

Chemical synthesis of an artificially branched hairpin ribozyme variant with RNA cleavage activity

Due to the development in the field of RNA synthesis over the past decade of years, preparation of RNA oligonucleotides longer than 50 nucleotides is possible today. In this report, we describe the chemical preparation of a branched RNA molecule with RNA cleavage activity consisting of 81 nucleotides. It is derived from the hairpin ribozyme, a small catalytic RNA occurring in nature. The hairpin ribozyme consists of two separately folded domains (loop A and loop B domain), which can be joined in a number of different ways without loss of activity. In the construct presented here, 2′-deoxy-N4-(6- hydroxyhexyl)-5-methylcytidine was introduced to connect the loop B domain with the loop A domain via an artificial branch. The synthesized branched RNA is able to catalyze the cleavage of a number of suitable substrates. Compared with the corresponding non-branched reverse-joined ribozyme it cleaves its substrates only 5-fold slower. Surprisingly, no ligation activity could be detected.