80988-38-1Relevant articles and documents
Asymmetric Hydrogenation of Pyridinium Salts with an Iridium Phosphole Catalyst
Chang, Mingxin,Huang, Yuhua,Liu, Shaodong,Chen, Yonggang,Krska, Shane W.,Davies, Ian W.,Zhang, Xumu
, p. 12761 - 12764 (2016/02/18)
Iridium-catalyzed asymmetric hydrogenation of N-alkyl-2-alkylpyridinium salts provided 2-aryl-substituted piperidines with high levels of enantioselectivity. Simple benzyl and other alkyl groups successfully activated the challenging pyridine substrates toward hydrogenation. The use of the unusual chiral-phosphole-based MP2-SEGPHOS was the key to the success of this approach which provides a versatile and practical procedure for the synthesis of chiral piperidines. Ring to ring: Simple N-benzyl and N-alkyl groups successfully activated pyridine substrates toward hydrogenation. The use of the unusual chiral phosphole-based ligand L was the key to the success of this approach, which provides a versatile and practical procedure for the synthesis of chiral piperidines. cod=1,5-cyclooctadiene.
