81008-09-5

Basic information

• Product Name: 4-(3,4-dichlorophenyl)-2-hydroxy-4-oxobutanoic acid
• Synonyms: 2-hydroxy-4-(3,4-dichlorophenyl)-4-oxobutanoic acid; benzenebutanoic acid, 3,4-dichloro-alpha-hydroxy-gamma-oxo-
• CAS NO: 81008-09-5
• Molecular Formula: C₁₀H₈Cl₂O₄
• Molecular Weight: 263.0741
• Mol File: 81008-09-5.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 510.3°C at 760 mmHg
• Flash Point: 262.4°C
• Density: 1.543g/cm³
• Vapor Pressure: 3.09E-11mmHg at 25°C
• Refractive Index: 1.601
• CAS DataBase Reference: 4-(3,4-dichlorophenyl)-2-hydroxy-4-oxobutanoic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 4-(3,4-dichlorophenyl)-2-hydroxy-4-oxobutanoic acid(81008-09-5)
• EPA Substance Registry System: 4-(3,4-dichlorophenyl)-2-hydroxy-4-oxobutanoic acid(81008-09-5)

Safety Data

• Hazardous Substances Data: 81008-09-5(Hazardous Substances Data)

Upstream product

• 2642-63-9 3',4'-dichloroacetophenone 
• 563-96-2 2,2-dihydroxyacetic acid 
• 298-12-4 Glyoxilic acid 

Relevant articles and documents

Substituted piperazines and diazepanes

A novel class of substituted piperazines and diazepanes, pharmaceutical compositions comprising them and use thereof in the treatment of diseases and disorders related to the histamine H3 receptor. More particularly, the compounds are useful for the treatment of diseases and disorders in which an interaction with the histamine H3 receptor is beneficial.

Gastric anti-secretory, anti-ulcer and cytoprotective properties of substituted (E)-4-phenyl- and heteroaryl-4-oxo-2-butenoic acids

A class of anti-secretory, anti-ulcer and cytoprotective agents, the substituted (E)-4-phenyl and heteroaryl-4-oxo-2-butenoic acids, is described.This chemical structure is not related to those of any known anti-cholinergic drugs, histamine H2-receptor antagonists or prostaglandins.Five compounds, 4-(2-methoxyphenyl)- 15, 4-(4-methoxyphenyl)- 22, 4-(3,4-dimethoxyphenyl)- 32, 4-(3,4,5-trimethoxyphenyl)- 40, and 4-(2-furanyl)-4-oxo-2-butenoic acid 44, have cytoprotective activity at a very low dose (0.6 mg/kg, p.o.) and anti-secretory and anti-ulcer activities at higher doses.One of these compounds, RU 38086 40, has been selected for clinical evaluation.Keywords - anti-ulcer agents / cytoprotective agents / (E)-4-phenyl- and heteroaryl-4-oxo-2-butenoic acids.