81038-90-6

Basic information

• Product Name: N-(2-methylpropyl)-1,2-benzothiazol-3-amine 1,1-dioxide
• Synonyms: 1,2-benzisothiazol-3-amine, N-(2-methylpropyl)-, 1,1-dioxide; N-Isobutyl-1,2-benzothiazol-3-amine 1,1-dioxide
• CAS NO: 81038-90-6
• Molecular Formula: C₁₁H₁₄N₂O₂S
• Molecular Weight: 238.3061
• Mol File: 81038-90-6.mol
• Article Data: 2

Chemical Properties

• Boiling Point: 390.5°C at 760 mmHg
• Flash Point: 190°C
• Density: 1.31g/cm³
• Vapor Pressure: 2.63E-06mmHg at 25°C
• Refractive Index: 1.622
• CAS DataBase Reference: N-(2-methylpropyl)-1,2-benzothiazol-3-amine 1,1-dioxide(CAS DataBase Reference)
• NIST Chemistry Reference: N-(2-methylpropyl)-1,2-benzothiazol-3-amine 1,1-dioxide(81038-90-6)
• EPA Substance Registry System: N-(2-methylpropyl)-1,2-benzothiazol-3-amine 1,1-dioxide(81038-90-6)

Safety Data

• Hazardous Substances Data: 81038-90-6(Hazardous Substances Data)

Upstream product

• 5041-09-8 isobutylamine hydrochloride 
• 81-07-2 saccharin 

Relevant articles and documents

Pseudosaccharin amine derivatives: Synthesis and elastase inhibitory activity

Pseudosaccharin amines were synthesized from saccharin either by the reaction of pseudosaccharin chloride with amines, or via thiosaccharin which was treated with amines yielding thiosaccharinates, and their reaction with glacial acetic acid. This route gave lower yields than the first way. The synthesis of alkyl [(1,1-dioxo-benzo[d]isothiazol-3-yl)amino]alkanoates as possible Human Leukocyte Elastase (HLE) inhibitors was realized by the reaction between amino acid esters and pseudosaccharin chloride. Hydrolysis of the esters was possible under aqueous basic conditions. Selected compounds were screened for elastase inhibitory activity. Compounds 4k and 4m were found to be reversible inhibitors of HLE with Ki values of 45 μM and 60 μM.