81059-07-6Relevant articles and documents
6-[(4-Substituted piperazin-l-yl)thiocarbonylamino]benzazoles and their use
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, (2008/06/13)
The invention relates to a process for the manufacture of novel benzazole derivatives of the formula I STR1 in which R1 represents an optionally 4-substituted piperazino group or a group of the formula R2 --alk--X2 --, R2 represents optionally esterified carboxy or represents hydroxymethyl, alk represents lower alkylene or lower alkylidene, X1 and X2, independently of one another, each represents oxygen or sulphur, Ph represents 1,2-phenylene optionally substituted as well as by the group R1 --C(=X1)--NH--, X3 represents oxygen, sulphur or optionally substituted imino, and R3 represents optionally fluorine-substituted lower alkyl or cycloalkyl, and their salts. The compounds of the formula I, which have proved to be excellent micro- and macrofilaricides and schistosomacides, are manufactured according to methods known per se.
