810676-31-4Relevant articles and documents
Synthesis and structure-activity relationship of daphnetin derivatives as potent antioxidant agents
Xia, Yangliu,Chen, Chen,Liu, Yong,Ge, Guangbo,Dou, Tongyi,Wang, Ping
supporting information, (2018/10/05)
In this study, daphnetin 1 was chosen as the lead compound, and C-3 or C-4-substituted daphnetins were designed and synthesized to explore the potential relationship between the antioxidant activities and the chemical structures of daphnetin derivatives. The antioxidant activities of the generated compounds were evaluated utilizing the free radical scavenging effect on 2,2-diphenyl-1-picrylhydrazyl, 2,2-azinobis-(3-ethylbenzthiazoline-6-sulfonate) cation, and the ferric reducing power assays, and were then compared with those of the standard antioxidant Trolox. The results showed that the catechol group was the key pharmacophore for the antioxidant activity of the daphnetins. The introduction of an electron-withdrawing hydrophilic group at the C-4 position of daphnetin enhanced the antioxidative capacity, but this trend was not observed for C-3 substitution. In addition, introduction of a a hydrophobic phenyl group exerted negative effects on the antioxidant activity in both the C-3 and C-4 substitutions. Among all of the derivatives tested, the most powerful antioxidant was 4-carboxymethyl daphnetin (compound 9), for which the strongest antioxidant activity was observed in all of the assays. In addition, compound 9 also displayed strong pharmaceutical properties in the form of metabolic stability. To summarize, compound 9 holds great potential to be developed as an antioxidant agent with excellent antioxidant activity and proper pharmacokinetic behavior.
New green, recyclable magnetic nanoparticles supported amino acids as simple heterogeneous catalysts for knoevenagel condensation
Girija,Naik, H.S. Bhojya,Kumar, B. Vinay,Sudhamani,Harish
, p. 468 - 477 (2013/08/23)
Coumarin derivatives were synthesized using magnetically recoverable iron oxide nanoparticles supported amino acids as heterogeneous catalysts via one-pot multi component reaction using MW irradiation. Easy recovery of the catalyst using an external magne
ZnO/MgO Containing ZnO Nanoparticles as a Highly Effective Heterogeneous Base Catalyst for the Synthesis of 4H-Pyrans and Coumarins in [bmim]BF 4
Valizadeh,Azimi
experimental part, p. 123 - 130 (2012/01/03)
4H-Pyrans and coumarins were synthesized through one-pot reactions using ZnO/MgO solid sample containing ZnO nanoparticles as an efficient reusable catalyst in ionic liquid, [bmim]BF4. The catalyst is inexpensive and readily available, stable and storable
