81069-92-3

Basic information

• Product Name: (L,D)-1-(N-phenylacetylamino)ethylphosphonic acid
• Synonyms: (L,D)-1-(N-phenylacetylamino)ethylphosphonic acid
• CAS NO: 81069-92-3
• Molecular Weight: 243.199
• Mol File: 81069-92-3.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: (L,D)-1-(N-phenylacetylamino)ethylphosphonic acid(CAS DataBase Reference)
• NIST Chemistry Reference: (L,D)-1-(N-phenylacetylamino)ethylphosphonic acid(81069-92-3)
• EPA Substance Registry System: (L,D)-1-(N-phenylacetylamino)ethylphosphonic acid(81069-92-3)

Safety Data

• Hazardous Substances Data: 81069-92-3(Hazardous Substances Data)

Upstream product

• 145728-52-5 1-(N-phenylacetylamino)ethylphosphonic acid dimethyl ester 
• 103-80-0 phenylacetyl chloride 
• 135362-53-7 1-(N-Phenylacetylamino)ethylphosphonic acid diisopropyl ester 
• 17966-65-3 N-phenylacetylalanine 

Downstream Products

• 6323-97-3 (L)-1-aminoethylphosphonic acid 
• 79879-28-0 (D)-1-(N-phenylacetylamino)ethylphosphonic acid 
• 130325-37-0 (S)-1-(N-phenylacetylamino)ethylphosphonic acid 
• 6323-97-3 (D)-1-aminoethylphosphonic acid 
• 145728-52-5 1-(N-phenylacetylamino)ethylphosphonic acid dimethyl ester 

Relevant articles and documents

Penicillin G acylase-mediated kinetic resolution of racemic 1-(N-acylamino)alkylphosphonic and 1-(N-acylamino)alkylphosphinic acids and their esters

Extensive studies on the penicillin G acylase-mediated kinetic resolution of N-acylated 1-aminoalkylphosphonic and 1-aminoalkylphosphinic acids as well as their esters were carried out to recognise the relationships between the substrate structure, reacti

Preparation of optically active 1-aminoalkylphosphonic acids by stereoselective enzymatic hydrolysis of racemic N-acylated 1-aminoalkylphosphonic acids

N-Phenylacetylated derivatives of 1-aminoalkylphosphonic acids were synthesized and high enantioselectivity of their hydrolysis by penicillin acylase (EC 3.5.1.11) was demonstrated. Stereoselective enzymatic hydrolysis of racemic 1-(N-phenylacetylamino) alkylphosphonic acids was used for preparation of enantiomeric 1-aminoalkylphosphonic acids. The kinetic regularities of penicillin acylase catalyzed hydrolysis were established and the biocatalytic process was optimized to increase the optical purity and the yield of the optically active product.